Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases

Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies. Objective: To investigate BCC invasion depth variation by subtype and anatomic site. Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic. Results: Descendin...

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Autores principales:	John H. Pyne, Esther Myint, Elizabeth M. Barr, Simon P. Clark, Ruihang Hou
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2018
Materias:	basal cell carcinoma superficial nodular infiltrating micronodular depth Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/6f510b2d48d54e44bdd521343d34de5b
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spelling	oai:doaj.org-article:6f510b2d48d54e44bdd521343d34de5b2021-11-17T08:29:59ZBasal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases10.5826/dpc.0804a132160-9381https://doaj.org/article/6f510b2d48d54e44bdd521343d34de5b2018-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/439https://doaj.org/toc/2160-9381Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies. Objective: To investigate BCC invasion depth variation by subtype and anatomic site. Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic. Results: Descending mean depths for a total of 4,565 BCC cases by subtype were as follows: nodulocystic, 1.9 mm (n = 84, 95% CI: 1.70–2.03, P = 0.66); nodular, 1.6 mm (n = 947, 95% CI: 1.53–1.63, P < 0.0001); aggressive, 1.5 mm (n = 925, 95% CI: 1.44–1.59, P < 0.0001); superficial combined with nodular, 0.9 mm (n = 1,081, 95% CI: 0.83-0.90, P < 0.0001); and superficial, 0.3 mm (n = 1,528, 95% CI: 0.32-0.36, P < 0.0001). Deeper invasion was associated with increased chronic sunlight exposed sites. The deepest aggressive BCCs occurred on the neck with a mean depth of 1.8 mm (n = 46, 95% CI:1.47–2.21). Conclusion: We found significant differences in the depth of invasion for BCCs by sex, subtype, and anatomic site. For BCC with characteristics matching this study, overall adequate microscopic excision depths are proposed: superficial, 1.0 mm; superficial combined with nodular, 2.0 mm; nodular, 3.0 mm; and aggressive, 3.0 mm. John H. PyneEsther MyintElizabeth M. BarrSimon P. ClarkRuihang HouMattioli1885articlebasal cell carcinomasuperficialnodularinfiltratingmicronodulardepthDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 8, Iss 4 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	basal cell carcinoma superficial nodular infiltrating micronodular depth Dermatology RL1-803
spellingShingle	basal cell carcinoma superficial nodular infiltrating micronodular depth Dermatology RL1-803 John H. Pyne Esther Myint Elizabeth M. Barr Simon P. Clark Ruihang Hou Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
description	Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies. Objective: To investigate BCC invasion depth variation by subtype and anatomic site. Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic. Results: Descending mean depths for a total of 4,565 BCC cases by subtype were as follows: nodulocystic, 1.9 mm (n = 84, 95% CI: 1.70–2.03, P = 0.66); nodular, 1.6 mm (n = 947, 95% CI: 1.53–1.63, P < 0.0001); aggressive, 1.5 mm (n = 925, 95% CI: 1.44–1.59, P < 0.0001); superficial combined with nodular, 0.9 mm (n = 1,081, 95% CI: 0.83-0.90, P < 0.0001); and superficial, 0.3 mm (n = 1,528, 95% CI: 0.32-0.36, P < 0.0001). Deeper invasion was associated with increased chronic sunlight exposed sites. The deepest aggressive BCCs occurred on the neck with a mean depth of 1.8 mm (n = 46, 95% CI:1.47–2.21). Conclusion: We found significant differences in the depth of invasion for BCCs by sex, subtype, and anatomic site. For BCC with characteristics matching this study, overall adequate microscopic excision depths are proposed: superficial, 1.0 mm; superficial combined with nodular, 2.0 mm; nodular, 3.0 mm; and aggressive, 3.0 mm.
format	article
author	John H. Pyne Esther Myint Elizabeth M. Barr Simon P. Clark Ruihang Hou
author_facet	John H. Pyne Esther Myint Elizabeth M. Barr Simon P. Clark Ruihang Hou
author_sort	John H. Pyne
title	Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
title_short	Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
title_full	Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
title_fullStr	Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
title_full_unstemmed	Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
title_sort	basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases
publisher	Mattioli1885
publishDate	2018
url	https://doaj.org/article/6f510b2d48d54e44bdd521343d34de5b
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Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases

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