Microbicidal Activity of Hypothiocyanite against Pneumococcus

Infections caused by <i>Streptococcus pneumoniae</i> (pneumococcus, <i>Spn</i>) manifest in several forms such as pneumonia, meningitis, sinusitis or otitis media and are associated with severe morbidity and mortality worldwide. While current vaccines and antibiotics are avai...

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Autores principales:	Edriss Yassine, Balázs Rada
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Streptococcus pneumoniae</i> hypothiocyanite microbicidal pneumococcus OSCN- Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6f51330906ab4d41a58830bcc229564a
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spelling	oai:doaj.org-article:6f51330906ab4d41a58830bcc229564a2021-11-25T16:22:38ZMicrobicidal Activity of Hypothiocyanite against Pneumococcus10.3390/antibiotics101113132079-6382https://doaj.org/article/6f51330906ab4d41a58830bcc229564a2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1313https://doaj.org/toc/2079-6382Infections caused by <i>Streptococcus pneumoniae</i> (pneumococcus, <i>Spn</i>) manifest in several forms such as pneumonia, meningitis, sinusitis or otitis media and are associated with severe morbidity and mortality worldwide. While current vaccines and antibiotics are available to treat <i>Spn</i> infections, the rise of antibiotic resistance and limitations of the vaccines to only certain <i>Spn</i> serotypes urge the development of novel treatments against <i>Spn</i>. Hypothiocyanite (OSCN-) is a natural antimicrobial product produced by the body’s own innate immune system to fight a variety of pathogens. We recently showed that OSCN- is also capable of killing <i>Spn</i> in vitro. OSCN- is an oxidative agent attacking microbes in a nonspecific manner, is safe for the host and also has anti-inflammatory effects that make it an ideal candidate to treat a variety of infections in humans. However, OSCN- has a short life span that makes its use, dosage and administration more problematic. This minireview discusses the antimicrobial mechanism of action of OSCN- against <i>Spn</i> and elaborates on the potential therapeutic use of OSCN- against <i>Spn</i> and other infectious agents, either alone or in combination with other therapeutic approaches.Edriss YassineBalázs RadaMDPI AGarticle<i>Streptococcus pneumoniae</i>hypothiocyanitemicrobicidalpneumococcusOSCN-Therapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1313, p 1313 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Streptococcus pneumoniae</i> hypothiocyanite microbicidal pneumococcus OSCN- Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Streptococcus pneumoniae</i> hypothiocyanite microbicidal pneumococcus OSCN- Therapeutics. Pharmacology RM1-950 Edriss Yassine Balázs Rada Microbicidal Activity of Hypothiocyanite against Pneumococcus
description	Infections caused by <i>Streptococcus pneumoniae</i> (pneumococcus, <i>Spn</i>) manifest in several forms such as pneumonia, meningitis, sinusitis or otitis media and are associated with severe morbidity and mortality worldwide. While current vaccines and antibiotics are available to treat <i>Spn</i> infections, the rise of antibiotic resistance and limitations of the vaccines to only certain <i>Spn</i> serotypes urge the development of novel treatments against <i>Spn</i>. Hypothiocyanite (OSCN-) is a natural antimicrobial product produced by the body’s own innate immune system to fight a variety of pathogens. We recently showed that OSCN- is also capable of killing <i>Spn</i> in vitro. OSCN- is an oxidative agent attacking microbes in a nonspecific manner, is safe for the host and also has anti-inflammatory effects that make it an ideal candidate to treat a variety of infections in humans. However, OSCN- has a short life span that makes its use, dosage and administration more problematic. This minireview discusses the antimicrobial mechanism of action of OSCN- against <i>Spn</i> and elaborates on the potential therapeutic use of OSCN- against <i>Spn</i> and other infectious agents, either alone or in combination with other therapeutic approaches.
format	article
author	Edriss Yassine Balázs Rada
author_facet	Edriss Yassine Balázs Rada
author_sort	Edriss Yassine
title	Microbicidal Activity of Hypothiocyanite against Pneumococcus
title_short	Microbicidal Activity of Hypothiocyanite against Pneumococcus
title_full	Microbicidal Activity of Hypothiocyanite against Pneumococcus
title_fullStr	Microbicidal Activity of Hypothiocyanite against Pneumococcus
title_full_unstemmed	Microbicidal Activity of Hypothiocyanite against Pneumococcus
title_sort	microbicidal activity of hypothiocyanite against pneumococcus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f51330906ab4d41a58830bcc229564a
work_keys_str_mv	AT edrissyassine microbicidalactivityofhypothiocyaniteagainstpneumococcus AT balazsrada microbicidalactivityofhypothiocyaniteagainstpneumococcus
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Microbicidal Activity of Hypothiocyanite against Pneumococcus

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