Age-related changes in liver metabolism and antioxidant capacity of laying hens

ABSTRACT: This study aimed to investigate the age-related changes of hepatic metabolism and antioxidant capacity of laying hens at 3 different ages. A total of 192 Hy-line Brown laying hens were assigned into 3 groups: 1) 195-day-old (D195 group); 2) 340-day-old (D340 group); 3) 525-day-old (D525 gr...

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Autores principales:	Y.F. Gu, Y.P. Chen, R. Jin, C. Wang, C. Wen, Y.M. Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	age antioxidant capacity laying hen liver function metabolism Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/6f5453cd3f424e2b817e9d58176c4d7b
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spelling	oai:doaj.org-article:6f5453cd3f424e2b817e9d58176c4d7b2021-11-24T04:22:00ZAge-related changes in liver metabolism and antioxidant capacity of laying hens0032-579110.1016/j.psj.2021.101478https://doaj.org/article/6f5453cd3f424e2b817e9d58176c4d7b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0032579121005009https://doaj.org/toc/0032-5791ABSTRACT: This study aimed to investigate the age-related changes of hepatic metabolism and antioxidant capacity of laying hens at 3 different ages. A total of 192 Hy-line Brown laying hens were assigned into 3 groups: 1) 195-day-old (D195 group); 2) 340-day-old (D340 group); 3) 525-day-old (D525 group). Each group replicated 8 times with 8 hens at the same age. Higher activity of aspartate aminotransferase and lower contents of total protein and globulin were observed in the serum of 525-day-old hens in comparison with their 195-day-old counterparts (P < 0.05). The 525-day-old hens accumulated higher contents of total cholesterol and triglyceride in the liver than 195-day-old birds. Additionally, compared with hens from D195 or D340 group, 525-day-old birds exhibited a lower circulating estradiol level (P < 0.05). For antioxidant capacity, birds in the D525 group showed a higher malondialdehyde concentration in both serum and liver as compared with D195 or D340 group (P < 0.05). The 525-day-old hens also exhibited lower glutathione peroxidase activities in both serum and liver when compared with 195-day-old birds (P < 0.05). Simultaneously, there was a decline of hepatic superoxide dismutase activity in the D525 group in comparison with D195 group (P < 0.05). Compared with 195-day-old counterparts, 340-day-old birds upregulated the mRNA abundance of nuclear factor erythroid-2 related factor 2 and glutathione peroxidase 1 in the liver (P < 0.05). In contrast, hens from D525 group showed the downregulation of hepatic nuclear factor erythroid-2 related factor 2, NAD(P)H quinone dehydrogenase 1, and superoxide dismutase 1 when compared with D340 group (P < 0.05). These results indicated that increasing age can adversely affect liver metabolism and function of laying hens.Y.F. GuY.P. ChenR. JinC. WangC. WenY.M. ZhouElsevierarticleageantioxidant capacitylaying henliver functionmetabolismAnimal cultureSF1-1100ENPoultry Science, Vol 100, Iss 12, Pp 101478- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	age antioxidant capacity laying hen liver function metabolism Animal culture SF1-1100
spellingShingle	age antioxidant capacity laying hen liver function metabolism Animal culture SF1-1100 Y.F. Gu Y.P. Chen R. Jin C. Wang C. Wen Y.M. Zhou Age-related changes in liver metabolism and antioxidant capacity of laying hens
description	ABSTRACT: This study aimed to investigate the age-related changes of hepatic metabolism and antioxidant capacity of laying hens at 3 different ages. A total of 192 Hy-line Brown laying hens were assigned into 3 groups: 1) 195-day-old (D195 group); 2) 340-day-old (D340 group); 3) 525-day-old (D525 group). Each group replicated 8 times with 8 hens at the same age. Higher activity of aspartate aminotransferase and lower contents of total protein and globulin were observed in the serum of 525-day-old hens in comparison with their 195-day-old counterparts (P < 0.05). The 525-day-old hens accumulated higher contents of total cholesterol and triglyceride in the liver than 195-day-old birds. Additionally, compared with hens from D195 or D340 group, 525-day-old birds exhibited a lower circulating estradiol level (P < 0.05). For antioxidant capacity, birds in the D525 group showed a higher malondialdehyde concentration in both serum and liver as compared with D195 or D340 group (P < 0.05). The 525-day-old hens also exhibited lower glutathione peroxidase activities in both serum and liver when compared with 195-day-old birds (P < 0.05). Simultaneously, there was a decline of hepatic superoxide dismutase activity in the D525 group in comparison with D195 group (P < 0.05). Compared with 195-day-old counterparts, 340-day-old birds upregulated the mRNA abundance of nuclear factor erythroid-2 related factor 2 and glutathione peroxidase 1 in the liver (P < 0.05). In contrast, hens from D525 group showed the downregulation of hepatic nuclear factor erythroid-2 related factor 2, NAD(P)H quinone dehydrogenase 1, and superoxide dismutase 1 when compared with D340 group (P < 0.05). These results indicated that increasing age can adversely affect liver metabolism and function of laying hens.
format	article
author	Y.F. Gu Y.P. Chen R. Jin C. Wang C. Wen Y.M. Zhou
author_facet	Y.F. Gu Y.P. Chen R. Jin C. Wang C. Wen Y.M. Zhou
author_sort	Y.F. Gu
title	Age-related changes in liver metabolism and antioxidant capacity of laying hens
title_short	Age-related changes in liver metabolism and antioxidant capacity of laying hens
title_full	Age-related changes in liver metabolism and antioxidant capacity of laying hens
title_fullStr	Age-related changes in liver metabolism and antioxidant capacity of laying hens
title_full_unstemmed	Age-related changes in liver metabolism and antioxidant capacity of laying hens
title_sort	age-related changes in liver metabolism and antioxidant capacity of laying hens
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6f5453cd3f424e2b817e9d58176c4d7b
work_keys_str_mv	AT yfgu agerelatedchangesinlivermetabolismandantioxidantcapacityoflayinghens AT ypchen agerelatedchangesinlivermetabolismandantioxidantcapacityoflayinghens AT rjin agerelatedchangesinlivermetabolismandantioxidantcapacityoflayinghens AT cwang agerelatedchangesinlivermetabolismandantioxidantcapacityoflayinghens AT cwen agerelatedchangesinlivermetabolismandantioxidantcapacityoflayinghens AT ymzhou agerelatedchangesinlivermetabolismandantioxidantcapacityoflayinghens
_version_	1718416039669137408

Age-related changes in liver metabolism and antioxidant capacity of laying hens

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