A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.

The polyglutamic acid/peptoid 1 (QM56) nanoconjugate inhibits apoptosis by interfering with Apaf-1 binding to procaspase-9. We now describe anti-inflammatory properties of QM56 in mouse kidney and renal cell models.In cultured murine tubular cells, QM56 inhibited the inflammatory response to Tweak,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alvaro C Ucero, Sergio Berzal, Carlos Ocaña-Salceda, Mónica Sancho, Mar Orzáez, Angel Messeguer, Marta Ruiz-Ortega, Jesús Egido, María J Vicent, Alberto Ortiz, Adrián M Ramos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f5a9a96097b45528fc4ebcc8d5f0ccc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f5a9a96097b45528fc4ebcc8d5f0ccc
record_format	dspace
spelling	oai:doaj.org-article:6f5a9a96097b45528fc4ebcc8d5f0ccc2021-11-18T08:02:56ZA polymeric nanomedicine diminishes inflammatory events in renal tubular cells.1932-620310.1371/journal.pone.0051992https://doaj.org/article/6f5a9a96097b45528fc4ebcc8d5f0ccc2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300960/?tool=EBIhttps://doaj.org/toc/1932-6203The polyglutamic acid/peptoid 1 (QM56) nanoconjugate inhibits apoptosis by interfering with Apaf-1 binding to procaspase-9. We now describe anti-inflammatory properties of QM56 in mouse kidney and renal cell models.In cultured murine tubular cells, QM56 inhibited the inflammatory response to Tweak, a non-apoptotic stimulus. Tweak induced MCP-1 and Rantes synthesis through JAK2 kinase and NF-κB activation. Similar to JAK2 kinase inhibitors, QM56 inhibited Tweak-induced NF-κB transcriptional activity and chemokine expression, despite failing to inhibit NF-κB-p65 nuclear translocation and NF-κB DNA binding. QM56 prevented JAK2 activation and NF-κB-p65(Ser536) phosphorylation. The anti-inflammatory effect and JAK2 inhibition by QM56 were observed in Apaf-1(-/-) cells. In murine acute kidney injury, QM56 decreased tubular cell apoptosis and kidney inflammation as measured by down-modulations of MCP-1 and Rantes mRNA expression, immune cell infiltration and activation of the JAK2-dependent inflammatory pathway.In conclusion, QM56 has an anti-inflammatory activity which is independent from its role as inhibitor of Apaf-1 and apoptosis and may have potential therapeutic relevance.Alvaro C UceroSergio BerzalCarlos Ocaña-SalcedaMónica SanchoMar OrzáezAngel MesseguerMarta Ruiz-OrtegaMarta Ruiz-OrtegaJesús EgidoMaría J VicentAlberto OrtizAdrián M RamosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e51992 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alvaro C Ucero Sergio Berzal Carlos Ocaña-Salceda Mónica Sancho Mar Orzáez Angel Messeguer Marta Ruiz-Ortega Marta Ruiz-Ortega Jesús Egido María J Vicent Alberto Ortiz Adrián M Ramos A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
description	The polyglutamic acid/peptoid 1 (QM56) nanoconjugate inhibits apoptosis by interfering with Apaf-1 binding to procaspase-9. We now describe anti-inflammatory properties of QM56 in mouse kidney and renal cell models.In cultured murine tubular cells, QM56 inhibited the inflammatory response to Tweak, a non-apoptotic stimulus. Tweak induced MCP-1 and Rantes synthesis through JAK2 kinase and NF-κB activation. Similar to JAK2 kinase inhibitors, QM56 inhibited Tweak-induced NF-κB transcriptional activity and chemokine expression, despite failing to inhibit NF-κB-p65 nuclear translocation and NF-κB DNA binding. QM56 prevented JAK2 activation and NF-κB-p65(Ser536) phosphorylation. The anti-inflammatory effect and JAK2 inhibition by QM56 were observed in Apaf-1(-/-) cells. In murine acute kidney injury, QM56 decreased tubular cell apoptosis and kidney inflammation as measured by down-modulations of MCP-1 and Rantes mRNA expression, immune cell infiltration and activation of the JAK2-dependent inflammatory pathway.In conclusion, QM56 has an anti-inflammatory activity which is independent from its role as inhibitor of Apaf-1 and apoptosis and may have potential therapeutic relevance.
format	article
author	Alvaro C Ucero Sergio Berzal Carlos Ocaña-Salceda Mónica Sancho Mar Orzáez Angel Messeguer Marta Ruiz-Ortega Marta Ruiz-Ortega Jesús Egido María J Vicent Alberto Ortiz Adrián M Ramos
author_facet	Alvaro C Ucero Sergio Berzal Carlos Ocaña-Salceda Mónica Sancho Mar Orzáez Angel Messeguer Marta Ruiz-Ortega Marta Ruiz-Ortega Jesús Egido María J Vicent Alberto Ortiz Adrián M Ramos
author_sort	Alvaro C Ucero
title	A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
title_short	A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
title_full	A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
title_fullStr	A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
title_full_unstemmed	A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
title_sort	polymeric nanomedicine diminishes inflammatory events in renal tubular cells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6f5a9a96097b45528fc4ebcc8d5f0ccc
work_keys_str_mv	AT alvarocucero apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT sergioberzal apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT carlosocanasalceda apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT monicasancho apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT marorzaez apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT angelmesseguer apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT martaruizortega apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT martaruizortega apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT jesusegido apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT mariajvicent apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT albertoortiz apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT adrianmramos apolymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT alvarocucero polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT sergioberzal polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT carlosocanasalceda polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT monicasancho polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT marorzaez polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT angelmesseguer polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT martaruizortega polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT martaruizortega polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT jesusegido polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT mariajvicent polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT albertoortiz polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells AT adrianmramos polymericnanomedicinediminishesinflammatoryeventsinrenaltubularcells
_version_	1718422608821616640

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.

Ejemplares similares