The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules

Microtubule organization requires γ-tubulin ring complexes (γTuRCs), but the mechanisms that control γTuRC-mediated microtubule nucleation are unclear. Here the authors show that the DNA polymerase δ catalytic subunit controls noncentrosomal γTuRC activity and regulates the organization of Golgi-der...

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Autores principales:	Yuehong Shen, Pengfei Liu, Taolue Jiang, Yu Hu, Franco K. C. Au, Robert Z. Qi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f5b05b483a54c0fb5c8e5a9fa0351b9
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id	oai:doaj.org-article:6f5b05b483a54c0fb5c8e5a9fa0351b9
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spelling	oai:doaj.org-article:6f5b05b483a54c0fb5c8e5a9fa0351b92021-12-02T14:40:49ZThe catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules10.1038/s41467-017-00694-22041-1723https://doaj.org/article/6f5b05b483a54c0fb5c8e5a9fa0351b92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00694-2https://doaj.org/toc/2041-1723Microtubule organization requires γ-tubulin ring complexes (γTuRCs), but the mechanisms that control γTuRC-mediated microtubule nucleation are unclear. Here the authors show that the DNA polymerase δ catalytic subunit controls noncentrosomal γTuRC activity and regulates the organization of Golgi-derived microtubules.Yuehong ShenPengfei LiuTaolue JiangYu HuFranco K. C. AuRobert Z. QiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuehong Shen Pengfei Liu Taolue Jiang Yu Hu Franco K. C. Au Robert Z. Qi The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules
description	Microtubule organization requires γ-tubulin ring complexes (γTuRCs), but the mechanisms that control γTuRC-mediated microtubule nucleation are unclear. Here the authors show that the DNA polymerase δ catalytic subunit controls noncentrosomal γTuRC activity and regulates the organization of Golgi-derived microtubules.
format	article
author	Yuehong Shen Pengfei Liu Taolue Jiang Yu Hu Franco K. C. Au Robert Z. Qi
author_facet	Yuehong Shen Pengfei Liu Taolue Jiang Yu Hu Franco K. C. Au Robert Z. Qi
author_sort	Yuehong Shen
title	The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules
title_short	The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules
title_full	The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules
title_fullStr	The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules
title_full_unstemmed	The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules
title_sort	catalytic subunit of dna polymerase δ inhibits γturc activity and regulates golgi-derived microtubules
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6f5b05b483a54c0fb5c8e5a9fa0351b9
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The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules

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