DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

Upon stress, translation of ATF4 is induced by reinitiating ribosomes following translation of short upstream open reading frames (uORFs). Here the authors show that translation re-initiation of ATF4 is mediated by the DENR-MCTS1 complex which acts on uORFs containing certain penultimate codons.

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Autores principales:	Jonathan Bohlen, Liza Harbrecht, Saioa Blanco, Katharina Clemm von Hohenberg, Kai Fenzl, Günter Kramer, Bernd Bukau, Aurelio A. Teleman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f5c73c82bd545db83b3c936664b634c
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spelling	oai:doaj.org-article:6f5c73c82bd545db83b3c936664b634c2021-12-02T17:25:45ZDENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF410.1038/s41467-020-18452-22041-1723https://doaj.org/article/6f5c73c82bd545db83b3c936664b634c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18452-2https://doaj.org/toc/2041-1723Upon stress, translation of ATF4 is induced by reinitiating ribosomes following translation of short upstream open reading frames (uORFs). Here the authors show that translation re-initiation of ATF4 is mediated by the DENR-MCTS1 complex which acts on uORFs containing certain penultimate codons.Jonathan BohlenLiza HarbrechtSaioa BlancoKatharina Clemm von HohenbergKai FenzlGünter KramerBernd BukauAurelio A. TelemanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Bohlen Liza Harbrecht Saioa Blanco Katharina Clemm von Hohenberg Kai Fenzl Günter Kramer Bernd Bukau Aurelio A. Teleman DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4
description	Upon stress, translation of ATF4 is induced by reinitiating ribosomes following translation of short upstream open reading frames (uORFs). Here the authors show that translation re-initiation of ATF4 is mediated by the DENR-MCTS1 complex which acts on uORFs containing certain penultimate codons.
format	article
author	Jonathan Bohlen Liza Harbrecht Saioa Blanco Katharina Clemm von Hohenberg Kai Fenzl Günter Kramer Bernd Bukau Aurelio A. Teleman
author_facet	Jonathan Bohlen Liza Harbrecht Saioa Blanco Katharina Clemm von Hohenberg Kai Fenzl Günter Kramer Bernd Bukau Aurelio A. Teleman
author_sort	Jonathan Bohlen
title	DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4
title_short	DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4
title_full	DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4
title_fullStr	DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4
title_full_unstemmed	DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4
title_sort	denr promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including atf4
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6f5c73c82bd545db83b3c936664b634c
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DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

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