CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine

Despite the immunogenicity of vaccines currently used in poultry, several pathogens, including avian influenza virus (AIV) and Newcastle disease virus (NDV), cause enormous economic losses to the global poultry industry. The efficacy of vaccines can be improved by the introduction of effective adjuv...

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Autores principales:	Eun-Seo Lee, Young-Jung Shim, W. A. Gayan Chathuranga, Young-Hoon Ahn, In-Joong Yoon, Sung-Sik Yoo, Jong-Soo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	avian influenza virus Newcastle disease virus vaccine adjuvant water-in-oil emulsion CAvant® WO-60 Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/6f5d16fd994a433993d0220cb8a0eb17
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spelling	oai:doaj.org-article:6f5d16fd994a433993d0220cb8a0eb172021-12-03T05:06:19ZCAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine2297-176910.3389/fvets.2021.730700https://doaj.org/article/6f5d16fd994a433993d0220cb8a0eb172021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.730700/fullhttps://doaj.org/toc/2297-1769Despite the immunogenicity of vaccines currently used in poultry, several pathogens, including avian influenza virus (AIV) and Newcastle disease virus (NDV), cause enormous economic losses to the global poultry industry. The efficacy of vaccines can be improved by the introduction of effective adjuvants. This study evaluated a novel water-in-oil emulsion adjuvant, CAvant® WO-60, which effectively enhanced both the immunogenicity of conserved influenza antigen sM2HA2 and inactivated whole H9N2 antigen (iH9N2). CAvant® WO-60 induced both humoral and cell-mediated immunity in mice and provided 100% protection from challenge with 10 LD50 of A/Aquatic bird/Korea/W81/2005 (H5N2) and A/Chicken/Korea/116/2004 (H9N2) AIV. Importantly, immunization of chickens with iH9N2 plus inactivated NDV LaSota (iNDV) bivalent inactivated vaccine emulsified in CAvant® WO-60 induced seroprotective levels of antigen-specific antibody responses. Taken together, these results suggested that CAvant® WO-60 is a promising adjuvant for poultry vaccines.Eun-Seo LeeYoung-Jung ShimW. A. Gayan ChathurangaYoung-Hoon AhnIn-Joong YoonSung-Sik YooJong-Soo LeeFrontiers Media S.A.articleavian influenza virusNewcastle disease virusvaccineadjuvantwater-in-oil emulsionCAvant® WO-60Veterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	avian influenza virus Newcastle disease virus vaccine adjuvant water-in-oil emulsion CAvant® WO-60 Veterinary medicine SF600-1100
spellingShingle	avian influenza virus Newcastle disease virus vaccine adjuvant water-in-oil emulsion CAvant® WO-60 Veterinary medicine SF600-1100 Eun-Seo Lee Young-Jung Shim W. A. Gayan Chathuranga Young-Hoon Ahn In-Joong Yoon Sung-Sik Yoo Jong-Soo Lee CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
description	Despite the immunogenicity of vaccines currently used in poultry, several pathogens, including avian influenza virus (AIV) and Newcastle disease virus (NDV), cause enormous economic losses to the global poultry industry. The efficacy of vaccines can be improved by the introduction of effective adjuvants. This study evaluated a novel water-in-oil emulsion adjuvant, CAvant® WO-60, which effectively enhanced both the immunogenicity of conserved influenza antigen sM2HA2 and inactivated whole H9N2 antigen (iH9N2). CAvant® WO-60 induced both humoral and cell-mediated immunity in mice and provided 100% protection from challenge with 10 LD50 of A/Aquatic bird/Korea/W81/2005 (H5N2) and A/Chicken/Korea/116/2004 (H9N2) AIV. Importantly, immunization of chickens with iH9N2 plus inactivated NDV LaSota (iNDV) bivalent inactivated vaccine emulsified in CAvant® WO-60 induced seroprotective levels of antigen-specific antibody responses. Taken together, these results suggested that CAvant® WO-60 is a promising adjuvant for poultry vaccines.
format	article
author	Eun-Seo Lee Young-Jung Shim W. A. Gayan Chathuranga Young-Hoon Ahn In-Joong Yoon Sung-Sik Yoo Jong-Soo Lee
author_facet	Eun-Seo Lee Young-Jung Shim W. A. Gayan Chathuranga Young-Hoon Ahn In-Joong Yoon Sung-Sik Yoo Jong-Soo Lee
author_sort	Eun-Seo Lee
title	CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
title_short	CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
title_full	CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
title_fullStr	CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
title_full_unstemmed	CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine
title_sort	cavant® wo-60 as an effective immunological adjuvant for avian influenza and newcastle disease vaccine
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6f5d16fd994a433993d0220cb8a0eb17
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CAvant® WO-60 as an Effective Immunological Adjuvant for Avian Influenza and Newcastle Disease Vaccine

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