Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats

Some oligosaccharides function as prebiotics and improve the dysbiosis of the gut microbiota, which affects the health of the host. Recent data suggests that neoagarooligosaccharides (NAOs) can exert anti-obesity effect. However, the effects of NAOs on the gut microbiota and its association with met...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ju Kyoung Oh, Robie Vasquez, Sang Hoon Kim, Je Hyeon Lee, Eun Joo Kim, Soon-Kwang Hong, Dae-Kyung Kang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Neoagarooligosaccharides Faecal microbiota Obesity Metabolic syndrome Rat Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6f5d19e475a74987a9325da8cdfaed46
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6f5d19e475a74987a9325da8cdfaed46
record_format	dspace
spelling	oai:doaj.org-article:6f5d19e475a74987a9325da8cdfaed462021-12-02T05:00:16ZNeoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats1756-464610.1016/j.jff.2021.104869https://doaj.org/article/6f5d19e475a74987a9325da8cdfaed462022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005181https://doaj.org/toc/1756-4646Some oligosaccharides function as prebiotics and improve the dysbiosis of the gut microbiota, which affects the health of the host. Recent data suggests that neoagarooligosaccharides (NAOs) can exert anti-obesity effect. However, the effects of NAOs on the gut microbiota and its association with metabolic syndrome have never been explored yet. Therefore, metabolic changes and the modulation of the gut microbiome after NAOs feeding to obese rats was investigated. NAOs supplementation reduced body weight, and improved lipogenesis, cholesterol and glucose levels. In addition, NAOs administration enriched several taxa negatively associated with obesity, specifically Eubacterium fissicatena and Ruminococcaceae UCG-005. The results indicated that the effects of NAOs on the improvement of obesity and glucose/lipid metabolism in obese rats may be associated with their modulatory effect on gut microbiome. The present findings provide novel insights on the anti-obesity mechanism of NAOs through gut microbiome modulation.Ju Kyoung OhRobie VasquezSang Hoon KimJe Hyeon LeeEun Joo KimSoon-Kwang HongDae-Kyung KangElsevierarticleNeoagarooligosaccharidesFaecal microbiotaObesityMetabolic syndromeRatNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 88, Iss , Pp 104869- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoagarooligosaccharides Faecal microbiota Obesity Metabolic syndrome Rat Nutrition. Foods and food supply TX341-641
spellingShingle	Neoagarooligosaccharides Faecal microbiota Obesity Metabolic syndrome Rat Nutrition. Foods and food supply TX341-641 Ju Kyoung Oh Robie Vasquez Sang Hoon Kim Je Hyeon Lee Eun Joo Kim Soon-Kwang Hong Dae-Kyung Kang Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats
description	Some oligosaccharides function as prebiotics and improve the dysbiosis of the gut microbiota, which affects the health of the host. Recent data suggests that neoagarooligosaccharides (NAOs) can exert anti-obesity effect. However, the effects of NAOs on the gut microbiota and its association with metabolic syndrome have never been explored yet. Therefore, metabolic changes and the modulation of the gut microbiome after NAOs feeding to obese rats was investigated. NAOs supplementation reduced body weight, and improved lipogenesis, cholesterol and glucose levels. In addition, NAOs administration enriched several taxa negatively associated with obesity, specifically Eubacterium fissicatena and Ruminococcaceae UCG-005. The results indicated that the effects of NAOs on the improvement of obesity and glucose/lipid metabolism in obese rats may be associated with their modulatory effect on gut microbiome. The present findings provide novel insights on the anti-obesity mechanism of NAOs through gut microbiome modulation.
format	article
author	Ju Kyoung Oh Robie Vasquez Sang Hoon Kim Je Hyeon Lee Eun Joo Kim Soon-Kwang Hong Dae-Kyung Kang
author_facet	Ju Kyoung Oh Robie Vasquez Sang Hoon Kim Je Hyeon Lee Eun Joo Kim Soon-Kwang Hong Dae-Kyung Kang
author_sort	Ju Kyoung Oh
title	Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats
title_short	Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats
title_full	Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats
title_fullStr	Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats
title_full_unstemmed	Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats
title_sort	neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/6f5d19e475a74987a9325da8cdfaed46
work_keys_str_mv	AT jukyoungoh neoagarooligosaccharidesmodulategutmicrobiotaandalleviatebodyweightgainandmetabolicsyndromeinhighfatdietinducedobeserats AT robievasquez neoagarooligosaccharidesmodulategutmicrobiotaandalleviatebodyweightgainandmetabolicsyndromeinhighfatdietinducedobeserats AT sanghoonkim neoagarooligosaccharidesmodulategutmicrobiotaandalleviatebodyweightgainandmetabolicsyndromeinhighfatdietinducedobeserats AT jehyeonlee neoagarooligosaccharidesmodulategutmicrobiotaandalleviatebodyweightgainandmetabolicsyndromeinhighfatdietinducedobeserats AT eunjookim neoagarooligosaccharidesmodulategutmicrobiotaandalleviatebodyweightgainandmetabolicsyndromeinhighfatdietinducedobeserats AT soonkwanghong neoagarooligosaccharidesmodulategutmicrobiotaandalleviatebodyweightgainandmetabolicsyndromeinhighfatdietinducedobeserats AT daekyungkang neoagarooligosaccharidesmodulategutmicrobiotaandalleviatebodyweightgainandmetabolicsyndromeinhighfatdietinducedobeserats
_version_	1718400834702671872

Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats

Ejemplares similares