Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic

Seasonal flu is caused by influenza infection, a virus that spreads easily in human population with periodical epidemic outbreaks. The high mutational rate of influenza viruses leads to the emergence of strains resistant to the current treatments. Due to that, scientific research is focusing on the...

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Autores principales:	Aurora Salamanca, Paula Almodóvar, Irene Jarama, Daniel González-Hedström, Marin Prodanov, Antonio Manuel Inarejos-García
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/6f5ea850efeb4451a2bb4c23a6c8df9e
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spelling	oai:doaj.org-article:6f5ea850efeb4451a2bb4c23a6c8df9e2021-12-01T00:06:36ZAnti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic2040-206610.1177/20402066211063391https://doaj.org/article/6f5ea850efeb4451a2bb4c23a6c8df9e2021-11-01T00:00:00Zhttps://doi.org/10.1177/20402066211063391https://doaj.org/toc/2040-2066Seasonal flu is caused by influenza infection, a virus that spreads easily in human population with periodical epidemic outbreaks. The high mutational rate of influenza viruses leads to the emergence of strains resistant to the current treatments. Due to that, scientific research is focusing on the development of new anti-influenza agents as alternative or complementary treatments. Olive tree ( Olea europaea L.) has been a source of ancestral remedies due to its antimicrobial activity. Thus, the aim of this study was to test the anti-influenza activity of a standardized olive leaf extract rich in elenolic acid (EA), Isenolic ® , compared with oseltamivir. Isenolic ® extract was characterized by High Performance Liquid Chromatography (HPLC)-Mass Spectrometry and its content in EA was determined by HPLC. Cytotoxicity, viral neuraminidase inhibitor activity and cell viability protection against influenza infection of Isenolic ® were tested in vitro using sialic acid overexpressing Madin-Darby Canine Kidney cells. Isenolic ® formulations showed a 4% and 8% dry basis. Oseltamivir and Isenolic ® extracts showed anti-influenza activity. The 8% Isenolic ® formulation showed a dose-dependent neuraminidase inhibitor activity higher than the 4% formulation, and preserved cell viability under viral infection. Thus, Isenolic ® become a promising natural alternative to existing influenza treatments.Aurora SalamancaPaula AlmodóvarIrene JaramaDaniel González-HedströmMarin ProdanovAntonio Manuel Inarejos-GarcíaSAGE PublishingarticleInfectious and parasitic diseasesRC109-216ENAntiviral Chemistry & Chemotherapy, Vol 29 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216
spellingShingle	Infectious and parasitic diseases RC109-216 Aurora Salamanca Paula Almodóvar Irene Jarama Daniel González-Hedström Marin Prodanov Antonio Manuel Inarejos-García Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic
description	Seasonal flu is caused by influenza infection, a virus that spreads easily in human population with periodical epidemic outbreaks. The high mutational rate of influenza viruses leads to the emergence of strains resistant to the current treatments. Due to that, scientific research is focusing on the development of new anti-influenza agents as alternative or complementary treatments. Olive tree ( Olea europaea L.) has been a source of ancestral remedies due to its antimicrobial activity. Thus, the aim of this study was to test the anti-influenza activity of a standardized olive leaf extract rich in elenolic acid (EA), Isenolic ® , compared with oseltamivir. Isenolic ® extract was characterized by High Performance Liquid Chromatography (HPLC)-Mass Spectrometry and its content in EA was determined by HPLC. Cytotoxicity, viral neuraminidase inhibitor activity and cell viability protection against influenza infection of Isenolic ® were tested in vitro using sialic acid overexpressing Madin-Darby Canine Kidney cells. Isenolic ® formulations showed a 4% and 8% dry basis. Oseltamivir and Isenolic ® extracts showed anti-influenza activity. The 8% Isenolic ® formulation showed a dose-dependent neuraminidase inhibitor activity higher than the 4% formulation, and preserved cell viability under viral infection. Thus, Isenolic ® become a promising natural alternative to existing influenza treatments.
format	article
author	Aurora Salamanca Paula Almodóvar Irene Jarama Daniel González-Hedström Marin Prodanov Antonio Manuel Inarejos-García
author_facet	Aurora Salamanca Paula Almodóvar Irene Jarama Daniel González-Hedström Marin Prodanov Antonio Manuel Inarejos-García
author_sort	Aurora Salamanca
title	Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic
title_short	Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic
title_full	Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic
title_fullStr	Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic
title_full_unstemmed	Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic
title_sort	anti-influenza virus activity of the elenolic acid rich olive leaf ( l.) extract isenolic
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/6f5ea850efeb4451a2bb4c23a6c8df9e
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Anti-influenza virus activity of the elenolic acid rich olive leaf ( L.) extract Isenolic

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