A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
Alterations in aurora kinase A (AURKA) activity can result in mitotic errors and have been associated with cancer progression. Here the authors develop a FRET biosensor which functionally replaces AURKA in cells, and show that its activation in the G1 phase is required to maintain microtubule stabil...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/6f622a19e820480b911dfb3e4b08287c |
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| Sumario: | Alterations in aurora kinase A (AURKA) activity can result in mitotic errors and have been associated with cancer progression. Here the authors develop a FRET biosensor which functionally replaces AURKA in cells, and show that its activation in the G1 phase is required to maintain microtubule stability. |
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