A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells

A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells

Alterations in aurora kinase A (AURKA) activity can result in mitotic errors and have been associated with cancer progression. Here the authors develop a FRET biosensor which functionally replaces AURKA in cells, and show that its activation in the G1 phase is required to maintain microtubule stabil...

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Autores principales: Giulia Bertolin, Florian Sizaire, Gaëtan Herbomel, David Reboutier, Claude Prigent, Marc Tramier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6f622a19e820480b911dfb3e4b08287c
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spelling oai:doaj.org-article:6f622a19e820480b911dfb3e4b08287c2021-12-02T16:58:00ZA FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells10.1038/ncomms126742041-1723https://doaj.org/article/6f622a19e820480b911dfb3e4b08287c2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12674https://doaj.org/toc/2041-1723Alterations in aurora kinase A (AURKA) activity can result in mitotic errors and have been associated with cancer progression. Here the authors develop a FRET biosensor which functionally replaces AURKA in cells, and show that its activation in the G1 phase is required to maintain microtubule stability.Giulia BertolinFlorian SizaireGaëtan HerbomelDavid ReboutierClaude PrigentMarc TramierNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Giulia Bertolin
Florian Sizaire
Gaëtan Herbomel
David Reboutier
Claude Prigent
Marc Tramier
A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
description Alterations in aurora kinase A (AURKA) activity can result in mitotic errors and have been associated with cancer progression. Here the authors develop a FRET biosensor which functionally replaces AURKA in cells, and show that its activation in the G1 phase is required to maintain microtubule stability.
format article
author Giulia Bertolin
Florian Sizaire
Gaëtan Herbomel
David Reboutier
Claude Prigent
Marc Tramier
author_facet Giulia Bertolin
Florian Sizaire
Gaëtan Herbomel
David Reboutier
Claude Prigent
Marc Tramier
author_sort Giulia Bertolin
title A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
title_short A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
title_full A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
title_fullStr A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
title_full_unstemmed A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
title_sort fret biosensor reveals spatiotemporal activation and functions of aurora kinase a in living cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/6f622a19e820480b911dfb3e4b08287c
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