Non-invasive assessment of telomere maintenance mechanisms in brain tumors

Telomerase expression and the alternative lengthening of telomeres pathway are hallmarks of cancer. Here, the authors show that, in primary brain tumors, these features are correlated with metabolic signatures detectable by metabolic imaging, suggesting that they can be used to non-invasively monito...

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Autores principales:	Pavithra Viswanath, Georgios Batsios, Joydeep Mukherjee, Anne Marie Gillespie, Peder E. Z. Larson, H. Artee Luchman, Joanna J. Phillips, Joseph F. Costello, Russell O. Pieper, Sabrina M. Ronen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f6728adc1b44addb32041508ef50b6c
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spelling	oai:doaj.org-article:6f6728adc1b44addb32041508ef50b6c2021-12-02T15:16:22ZNon-invasive assessment of telomere maintenance mechanisms in brain tumors10.1038/s41467-020-20312-y2041-1723https://doaj.org/article/6f6728adc1b44addb32041508ef50b6c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20312-yhttps://doaj.org/toc/2041-1723Telomerase expression and the alternative lengthening of telomeres pathway are hallmarks of cancer. Here, the authors show that, in primary brain tumors, these features are correlated with metabolic signatures detectable by metabolic imaging, suggesting that they can be used to non-invasively monitor telomere maintenance in brain tumours.Pavithra ViswanathGeorgios BatsiosJoydeep MukherjeeAnne Marie GillespiePeder E. Z. LarsonH. Artee LuchmanJoanna J. PhillipsJoseph F. CostelloRussell O. PieperSabrina M. RonenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pavithra Viswanath Georgios Batsios Joydeep Mukherjee Anne Marie Gillespie Peder E. Z. Larson H. Artee Luchman Joanna J. Phillips Joseph F. Costello Russell O. Pieper Sabrina M. Ronen Non-invasive assessment of telomere maintenance mechanisms in brain tumors
description	Telomerase expression and the alternative lengthening of telomeres pathway are hallmarks of cancer. Here, the authors show that, in primary brain tumors, these features are correlated with metabolic signatures detectable by metabolic imaging, suggesting that they can be used to non-invasively monitor telomere maintenance in brain tumours.
format	article
author	Pavithra Viswanath Georgios Batsios Joydeep Mukherjee Anne Marie Gillespie Peder E. Z. Larson H. Artee Luchman Joanna J. Phillips Joseph F. Costello Russell O. Pieper Sabrina M. Ronen
author_facet	Pavithra Viswanath Georgios Batsios Joydeep Mukherjee Anne Marie Gillespie Peder E. Z. Larson H. Artee Luchman Joanna J. Phillips Joseph F. Costello Russell O. Pieper Sabrina M. Ronen
author_sort	Pavithra Viswanath
title	Non-invasive assessment of telomere maintenance mechanisms in brain tumors
title_short	Non-invasive assessment of telomere maintenance mechanisms in brain tumors
title_full	Non-invasive assessment of telomere maintenance mechanisms in brain tumors
title_fullStr	Non-invasive assessment of telomere maintenance mechanisms in brain tumors
title_full_unstemmed	Non-invasive assessment of telomere maintenance mechanisms in brain tumors
title_sort	non-invasive assessment of telomere maintenance mechanisms in brain tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f6728adc1b44addb32041508ef50b6c
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Non-invasive assessment of telomere maintenance mechanisms in brain tumors

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