Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia

Abstract Schizophrenia is a chronic mental condition presenting a wide range of symptoms. Although it has a low prevalence compared to other mental conditions, it has a negative impact on social and occupational functions. This study aimed to assess the appropriateness of antipsychotic medications a...

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Autores principales:	Verónica Gamón, Isabel Hurtado, José Salazar-Fraile, Gabriel Sanfélix-Gimeno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f6740712b2c4c71b1f52dd010fdc157
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spelling	oai:doaj.org-article:6f6740712b2c4c71b1f52dd010fdc1572021-12-02T14:34:02ZTreatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia10.1038/s41598-021-92731-w2045-2322https://doaj.org/article/6f6740712b2c4c71b1f52dd010fdc1572021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92731-whttps://doaj.org/toc/2045-2322Abstract Schizophrenia is a chronic mental condition presenting a wide range of symptoms. Although it has a low prevalence compared to other mental conditions, it has a negative impact on social and occupational functions. This study aimed to assess the appropriateness of antipsychotic medications administered to schizophrenic patients and describe current treatment patterns for schizophrenia. A retrospective cohort study was conducted in all patients over the age of 15 with an active diagnosis of schizophrenia and treated with antipsychotics between 2008 and 2013 in the Valencia region. A total of 19,718 patients were eligible for inclusion. The main outcome assessed was inappropriateness of the pharmacotherapeutic management, including polypharmacy use. Altogether, 30.4% of patients received antipsychotic polypharmacy, and 6.8% were prescribed three or more antipsychotics. Overdosage affected 318 individuals (1.6%), and 21.5% used concomitant psychotropics without an associated psychiatric diagnosis. Women and people with a comorbid condition like anxiety or depression were less likely to receive antipsychotic polypharmacy. In contrast, increased polypharmacy was associated with concomitant treatment with other psychoactive drugs, and only in user on maintenance therapy, with more visits to the mental health hospital. Overall, we observed a high level of inappropriateness in antipsychotic prescriptions. Greater adherence to guidelines could maximize the benefits of antipsychotic medications while minimizing risk of adverse effects.Verónica GamónIsabel HurtadoJosé Salazar-FraileGabriel Sanfélix-GimenoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Verónica Gamón Isabel Hurtado José Salazar-Fraile Gabriel Sanfélix-Gimeno Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia
description	Abstract Schizophrenia is a chronic mental condition presenting a wide range of symptoms. Although it has a low prevalence compared to other mental conditions, it has a negative impact on social and occupational functions. This study aimed to assess the appropriateness of antipsychotic medications administered to schizophrenic patients and describe current treatment patterns for schizophrenia. A retrospective cohort study was conducted in all patients over the age of 15 with an active diagnosis of schizophrenia and treated with antipsychotics between 2008 and 2013 in the Valencia region. A total of 19,718 patients were eligible for inclusion. The main outcome assessed was inappropriateness of the pharmacotherapeutic management, including polypharmacy use. Altogether, 30.4% of patients received antipsychotic polypharmacy, and 6.8% were prescribed three or more antipsychotics. Overdosage affected 318 individuals (1.6%), and 21.5% used concomitant psychotropics without an associated psychiatric diagnosis. Women and people with a comorbid condition like anxiety or depression were less likely to receive antipsychotic polypharmacy. In contrast, increased polypharmacy was associated with concomitant treatment with other psychoactive drugs, and only in user on maintenance therapy, with more visits to the mental health hospital. Overall, we observed a high level of inappropriateness in antipsychotic prescriptions. Greater adherence to guidelines could maximize the benefits of antipsychotic medications while minimizing risk of adverse effects.
format	article
author	Verónica Gamón Isabel Hurtado José Salazar-Fraile Gabriel Sanfélix-Gimeno
author_facet	Verónica Gamón Isabel Hurtado José Salazar-Fraile Gabriel Sanfélix-Gimeno
author_sort	Verónica Gamón
title	Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia
title_short	Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia
title_full	Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia
title_fullStr	Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia
title_full_unstemmed	Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia
title_sort	treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f6740712b2c4c71b1f52dd010fdc157
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Treatment patterns and appropriateness of antipsychotic prescriptions in patients with schizophrenia

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