Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese

Goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) are the main agents associated with waterfowl parvovirus infections that caused great economic losses in the waterfowl industry. In 2020, a recombinant waterfowl parvovirus, 20-0910G, was isolated in a goose flock in Taiwan that experienced h...

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Autores principales:	Kuang-Po Li, Yu-Chen Hsu, Chih-An Lin, Poa-Chun Chang, Jui-Hung Shien, Hsien-Yueh Liu, Hua Yen, Shan-Chia Ou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	goose parvovirus (GPV) Muscovy duck parvovirus (MDPV) recombination Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/6f6a9a2d21ae45e3a7288570bc351065
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spelling	oai:doaj.org-article:6f6a9a2d21ae45e3a7288570bc3510652021-11-25T16:19:14ZMolecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese10.3390/ani111132112076-2615https://doaj.org/article/6f6a9a2d21ae45e3a7288570bc3510652021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3211https://doaj.org/toc/2076-2615Goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) are the main agents associated with waterfowl parvovirus infections that caused great economic losses in the waterfowl industry. In 2020, a recombinant waterfowl parvovirus, 20-0910G, was isolated in a goose flock in Taiwan that experienced high morbidity and mortality. The whole genome of 20-0910G was sequenced to investigate the genomic characteristics of this isolate. Recombination analysis revealed that, like Chinese rMDPVs, 20-0910G had a classical MDPV genomic backbone and underwent two recombination events with classical GPVs at the P9 promoter and partial VP3 gene regions. Phylogenetic analysis of the genomic sequence found that this goose-origin parvovirus was highly similar to the circulating recombinant MDPVs (rMDPVs) isolated from duck flocks in China. The results of experimental challenge tests showed that 20-0910G caused 100% mortality in goose embryos and in 1-day-old goslings by 11 and 12 days post-inoculation, respectively. Taken together, the results indicated that this goose-origin rMDPV was closely related to the duck-origin rMDPVs and was highly pathogenic to young geese.Kuang-Po LiYu-Chen HsuChih-An LinPoa-Chun ChangJui-Hung ShienHsien-Yueh LiuHua YenShan-Chia OuMDPI AGarticlegoose parvovirus (GPV)Muscovy duck parvovirus (MDPV)recombinationVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3211, p 3211 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	goose parvovirus (GPV) Muscovy duck parvovirus (MDPV) recombination Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	goose parvovirus (GPV) Muscovy duck parvovirus (MDPV) recombination Veterinary medicine SF600-1100 Zoology QL1-991 Kuang-Po Li Yu-Chen Hsu Chih-An Lin Poa-Chun Chang Jui-Hung Shien Hsien-Yueh Liu Hua Yen Shan-Chia Ou Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese
description	Goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) are the main agents associated with waterfowl parvovirus infections that caused great economic losses in the waterfowl industry. In 2020, a recombinant waterfowl parvovirus, 20-0910G, was isolated in a goose flock in Taiwan that experienced high morbidity and mortality. The whole genome of 20-0910G was sequenced to investigate the genomic characteristics of this isolate. Recombination analysis revealed that, like Chinese rMDPVs, 20-0910G had a classical MDPV genomic backbone and underwent two recombination events with classical GPVs at the P9 promoter and partial VP3 gene regions. Phylogenetic analysis of the genomic sequence found that this goose-origin parvovirus was highly similar to the circulating recombinant MDPVs (rMDPVs) isolated from duck flocks in China. The results of experimental challenge tests showed that 20-0910G caused 100% mortality in goose embryos and in 1-day-old goslings by 11 and 12 days post-inoculation, respectively. Taken together, the results indicated that this goose-origin rMDPV was closely related to the duck-origin rMDPVs and was highly pathogenic to young geese.
format	article
author	Kuang-Po Li Yu-Chen Hsu Chih-An Lin Poa-Chun Chang Jui-Hung Shien Hsien-Yueh Liu Hua Yen Shan-Chia Ou
author_facet	Kuang-Po Li Yu-Chen Hsu Chih-An Lin Poa-Chun Chang Jui-Hung Shien Hsien-Yueh Liu Hua Yen Shan-Chia Ou
author_sort	Kuang-Po Li
title	Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese
title_short	Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese
title_full	Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese
title_fullStr	Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese
title_full_unstemmed	Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese
title_sort	molecular characterization and pathogenicity of the novel recombinant muscovy duck parvovirus isolated from geese
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f6a9a2d21ae45e3a7288570bc351065
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Molecular Characterization and Pathogenicity of the Novel Recombinant Muscovy Duck Parvovirus Isolated from Geese

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