Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats

Abstract The impact of dietary soybean oil, lard and fish oil on physiological responses in middle age is little studied. In this study, we investigated the changes of oxidative stress, inflammatory cytokines, telomere length, and age-related gene expression in the liver of middle-aged rats in respo...

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Autores principales:	Yingqiu Li, Fan Zhao, Qiayu Wu, Mengjie Li, Yingying Zhu, Shangxin Song, Jing Zhu, Yafang Ma, He Li, Xuebin Shi, Xinglian Xu, Guanghong Zhou, Chunbao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f6badfcbd9e44249e52bf60d260207b
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spelling	oai:doaj.org-article:6f6badfcbd9e44249e52bf60d260207b2021-12-02T12:32:39ZFish oil diet may reduce inflammatory levels in the liver of middle-aged rats10.1038/s41598-017-06506-32045-2322https://doaj.org/article/6f6badfcbd9e44249e52bf60d260207b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06506-3https://doaj.org/toc/2045-2322Abstract The impact of dietary soybean oil, lard and fish oil on physiological responses in middle age is little studied. In this study, we investigated the changes of oxidative stress, inflammatory cytokines, telomere length, and age-related gene expression in the liver of middle-aged rats in response to the above three fat diets. Male Sprague Dawley rats (12 months old) were fed AIN-93M diets for 3 months, in which soybean oil was equivalently replaced by lard or fish oil. As compared to the lard diet, intake of fish oil diet significantly decreased body weight gain, white blood cell count, and levels of hepatic triacylglycerol, total cholesterol, fat accumulation, low-density lipoprotein, oxidative stress and inflammatory cytokines (P < 0.05), but increased telomere length (P < 0.05). On the other hand, lard diet and soybean oil diet showed great similarity in the above variables. PCR array analysis further indicated that fish oil diet significantly down-regulated gene expression related to inflammatory response, apoptosis, DNA binding, proteostasis and telomere attrition. Differentially expressed genes were enriched in the complement and coagulation cascades pathways. Such physiological and molecular responses could be due to different fatty acid composition in fish oil, lard and soybean oil.Yingqiu LiFan ZhaoQiayu WuMengjie LiYingying ZhuShangxin SongJing ZhuYafang MaHe LiXuebin ShiXinglian XuGuanghong ZhouChunbao LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yingqiu Li Fan Zhao Qiayu Wu Mengjie Li Yingying Zhu Shangxin Song Jing Zhu Yafang Ma He Li Xuebin Shi Xinglian Xu Guanghong Zhou Chunbao Li Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
description	Abstract The impact of dietary soybean oil, lard and fish oil on physiological responses in middle age is little studied. In this study, we investigated the changes of oxidative stress, inflammatory cytokines, telomere length, and age-related gene expression in the liver of middle-aged rats in response to the above three fat diets. Male Sprague Dawley rats (12 months old) were fed AIN-93M diets for 3 months, in which soybean oil was equivalently replaced by lard or fish oil. As compared to the lard diet, intake of fish oil diet significantly decreased body weight gain, white blood cell count, and levels of hepatic triacylglycerol, total cholesterol, fat accumulation, low-density lipoprotein, oxidative stress and inflammatory cytokines (P < 0.05), but increased telomere length (P < 0.05). On the other hand, lard diet and soybean oil diet showed great similarity in the above variables. PCR array analysis further indicated that fish oil diet significantly down-regulated gene expression related to inflammatory response, apoptosis, DNA binding, proteostasis and telomere attrition. Differentially expressed genes were enriched in the complement and coagulation cascades pathways. Such physiological and molecular responses could be due to different fatty acid composition in fish oil, lard and soybean oil.
format	article
author	Yingqiu Li Fan Zhao Qiayu Wu Mengjie Li Yingying Zhu Shangxin Song Jing Zhu Yafang Ma He Li Xuebin Shi Xinglian Xu Guanghong Zhou Chunbao Li
author_facet	Yingqiu Li Fan Zhao Qiayu Wu Mengjie Li Yingying Zhu Shangxin Song Jing Zhu Yafang Ma He Li Xuebin Shi Xinglian Xu Guanghong Zhou Chunbao Li
author_sort	Yingqiu Li
title	Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
title_short	Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
title_full	Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
title_fullStr	Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
title_full_unstemmed	Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
title_sort	fish oil diet may reduce inflammatory levels in the liver of middle-aged rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6f6badfcbd9e44249e52bf60d260207b
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Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats

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