Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment

Breast cancer, the most frequent cancer diagnosed among females, is associated with a high mortality rate worldwide. Alterations in the microbiota have been linked with breast cancer development, suggesting the possibility of discovering disease biomarkers. Metabolomics has emerged as an advanced pr...

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Autores principales:	Mysoon M. Al-Ansari, Reem H. AlMalki, Lina A. Dahabiyeh, Anas M. Abdel Rahman
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metabolomics microbiome microenvironment breast cancer Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6f6ce6b613fb493aad8404ea097f32f3
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spelling	oai:doaj.org-article:6f6ce6b613fb493aad8404ea097f32f32021-11-25T18:20:42ZMetabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment10.3390/metabo111107582218-1989https://doaj.org/article/6f6ce6b613fb493aad8404ea097f32f32021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/758https://doaj.org/toc/2218-1989Breast cancer, the most frequent cancer diagnosed among females, is associated with a high mortality rate worldwide. Alterations in the microbiota have been linked with breast cancer development, suggesting the possibility of discovering disease biomarkers. Metabolomics has emerged as an advanced promising analytical approach for profiling metabolic features associated with breast cancer subtypes, disease progression, and response to treatment. The microenvironment compromises non-cancerous cells such as fibroblasts and influences cancer progression with apparent phenotypes. This review discusses the role of metabolomics in studying metabolic dysregulation in breast cancer caused by the effect of the tumor microenvironment on multiple cells such as immune cells, fibroblasts, adipocytes, etc. Breast tumor cells have a unique metabolic profile through the elevation of glycolysis and the tricarboxylic acid cycle metabolism. This metabolic profile is highly sensitive to microbiota activity in the breast tissue microenvironment. Metabolomics shows great potential as a tool for monitoring metabolic dysregulation in tissue and associating the findings with microbiome expression.Mysoon M. Al-AnsariReem H. AlMalkiLina A. DahabiyehAnas M. Abdel RahmanMDPI AGarticlemetabolomicsmicrobiomemicroenvironmentbreast cancerMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 758, p 758 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics microbiome microenvironment breast cancer Microbiology QR1-502
spellingShingle	metabolomics microbiome microenvironment breast cancer Microbiology QR1-502 Mysoon M. Al-Ansari Reem H. AlMalki Lina A. Dahabiyeh Anas M. Abdel Rahman Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment
description	Breast cancer, the most frequent cancer diagnosed among females, is associated with a high mortality rate worldwide. Alterations in the microbiota have been linked with breast cancer development, suggesting the possibility of discovering disease biomarkers. Metabolomics has emerged as an advanced promising analytical approach for profiling metabolic features associated with breast cancer subtypes, disease progression, and response to treatment. The microenvironment compromises non-cancerous cells such as fibroblasts and influences cancer progression with apparent phenotypes. This review discusses the role of metabolomics in studying metabolic dysregulation in breast cancer caused by the effect of the tumor microenvironment on multiple cells such as immune cells, fibroblasts, adipocytes, etc. Breast tumor cells have a unique metabolic profile through the elevation of glycolysis and the tricarboxylic acid cycle metabolism. This metabolic profile is highly sensitive to microbiota activity in the breast tissue microenvironment. Metabolomics shows great potential as a tool for monitoring metabolic dysregulation in tissue and associating the findings with microbiome expression.
format	article
author	Mysoon M. Al-Ansari Reem H. AlMalki Lina A. Dahabiyeh Anas M. Abdel Rahman
author_facet	Mysoon M. Al-Ansari Reem H. AlMalki Lina A. Dahabiyeh Anas M. Abdel Rahman
author_sort	Mysoon M. Al-Ansari
title	Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment
title_short	Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment
title_full	Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment
title_fullStr	Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment
title_full_unstemmed	Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment
title_sort	metabolomics-microbiome crosstalk in the breast cancer microenvironment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f6ce6b613fb493aad8404ea097f32f3
work_keys_str_mv	AT mysoonmalansari metabolomicsmicrobiomecrosstalkinthebreastcancermicroenvironment AT reemhalmalki metabolomicsmicrobiomecrosstalkinthebreastcancermicroenvironment AT linaadahabiyeh metabolomicsmicrobiomecrosstalkinthebreastcancermicroenvironment AT anasmabdelrahman metabolomicsmicrobiomecrosstalkinthebreastcancermicroenvironment
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Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment

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