GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation

Abstract Behaviors central to the procurement and consumption of food are among those most fundamental to survival, but their inappropriate expression can lead to overeating and obesity. Nevertheless, we have a poor understanding of circuits that promote feeding independent of physiological demand....

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Autores principales:	Ciorana Roman-Ortiz, Jessica A. Guevara, Roger L. Clem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f6dd9e33070481e9f62418e84522216
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spelling	oai:doaj.org-article:6f6dd9e33070481e9f62418e845222162021-11-28T12:21:36ZGABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation10.1038/s41598-021-02157-72045-2322https://doaj.org/article/6f6dd9e33070481e9f62418e845222162021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02157-7https://doaj.org/toc/2045-2322Abstract Behaviors central to the procurement and consumption of food are among those most fundamental to survival, but their inappropriate expression can lead to overeating and obesity. Nevertheless, we have a poor understanding of circuits that promote feeding independent of physiological demand. Here we demonstrate that activation of basal forebrain (BF) GABAergic neurons results in consumption of food as well as non-food items in well-fed mice, and performance of fictive eating in the absence of ingestible materials. In addition, stimulation of these cells disrupts defensive threat responses and elicits reward-like motivational effects. Finally, BF GABAergic activity triggers skilled predatory attacks of live prey and prey-like objects, but not social targets. These effects were entirely recapitulated by selective stimulation of BF GABAergic projections to the periaqueductal gray (PAG). Our results outline a potent circuit mechanism for increased feeding through recruitment of distinct but synergistic behaviors, and add to growing evidence that PAG is an important integrator of feeding-related activity.Ciorana Roman-OrtizJessica A. GuevaraRoger L. ClemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ciorana Roman-Ortiz Jessica A. Guevara Roger L. Clem GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
description	Abstract Behaviors central to the procurement and consumption of food are among those most fundamental to survival, but their inappropriate expression can lead to overeating and obesity. Nevertheless, we have a poor understanding of circuits that promote feeding independent of physiological demand. Here we demonstrate that activation of basal forebrain (BF) GABAergic neurons results in consumption of food as well as non-food items in well-fed mice, and performance of fictive eating in the absence of ingestible materials. In addition, stimulation of these cells disrupts defensive threat responses and elicits reward-like motivational effects. Finally, BF GABAergic activity triggers skilled predatory attacks of live prey and prey-like objects, but not social targets. These effects were entirely recapitulated by selective stimulation of BF GABAergic projections to the periaqueductal gray (PAG). Our results outline a potent circuit mechanism for increased feeding through recruitment of distinct but synergistic behaviors, and add to growing evidence that PAG is an important integrator of feeding-related activity.
format	article
author	Ciorana Roman-Ortiz Jessica A. Guevara Roger L. Clem
author_facet	Ciorana Roman-Ortiz Jessica A. Guevara Roger L. Clem
author_sort	Ciorana Roman-Ortiz
title	GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
title_short	GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
title_full	GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
title_fullStr	GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
title_full_unstemmed	GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
title_sort	gabaergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f6dd9e33070481e9f62418e84522216
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GABAergic basal forebrain projections to the periaqueductal gray promote food consumption, reward and predation

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