Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma

Abstract The presence of parapapillary choroidal microvasculature dropout (CMvD) may affect optic nerve head (ONH) perfusion in glaucoma patients, since parapapillary choroidal vessels provide vascular supply to the neighboring ONH. However, it remains to be determined whether the presence of parapa...

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Autores principales:	Min Kyung Song, Joong Won Shin, Jin Yeong Lee, Ji Wook Hong, Michael S. Kook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f6e62b7eec143ab842c441b591d28f1
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spelling	oai:doaj.org-article:6f6e62b7eec143ab842c441b591d28f12021-12-02T18:47:08ZChoroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma10.1038/s41598-021-94755-82045-2322https://doaj.org/article/6f6e62b7eec143ab842c441b591d28f12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94755-8https://doaj.org/toc/2045-2322Abstract The presence of parapapillary choroidal microvasculature dropout (CMvD) may affect optic nerve head (ONH) perfusion in glaucoma patients, since parapapillary choroidal vessels provide vascular supply to the neighboring ONH. However, it remains to be determined whether the presence of parapapillary CMvD is associated with diminished perfusion in the nearby ONH. The present study investigated the spatial relationship between CMvD and ONH vessel density (ONH-VD) loss in open-angle glaucoma (OAG) eyes using optical coherence tomography angiography (OCT-A). This study included 48 OAG eyes with a single localized CMvD confined to the inferotemporal parapapillary sector and 48 OAG eyes without CMvD, matched for demographic and ocular characteristics. Global and regional ONH-VD values were compared between eyes with and without CMvD. The relationships between ONH-VD outcomes and clinical variables were assessed. ONH-VDs at the inferotemporal ONH sectors corresponding to the CMvD location were significantly lower in eyes with compared to those without CMvD. Multivariable linear regression analyses indicated that a lower inferotemporal ONH-VD was independently associated with CMvD presence and a greater CMvD angular extent (both P < 0.05). The localized presence of parapapillary CMvD in OAG eyes is significantly associated with ONH-VD loss in the neighboring ONH location, with a spatial correlation.Min Kyung SongJoong Won ShinJin Yeong LeeJi Wook HongMichael S. KookNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Kyung Song Joong Won Shin Jin Yeong Lee Ji Wook Hong Michael S. Kook Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma
description	Abstract The presence of parapapillary choroidal microvasculature dropout (CMvD) may affect optic nerve head (ONH) perfusion in glaucoma patients, since parapapillary choroidal vessels provide vascular supply to the neighboring ONH. However, it remains to be determined whether the presence of parapapillary CMvD is associated with diminished perfusion in the nearby ONH. The present study investigated the spatial relationship between CMvD and ONH vessel density (ONH-VD) loss in open-angle glaucoma (OAG) eyes using optical coherence tomography angiography (OCT-A). This study included 48 OAG eyes with a single localized CMvD confined to the inferotemporal parapapillary sector and 48 OAG eyes without CMvD, matched for demographic and ocular characteristics. Global and regional ONH-VD values were compared between eyes with and without CMvD. The relationships between ONH-VD outcomes and clinical variables were assessed. ONH-VDs at the inferotemporal ONH sectors corresponding to the CMvD location were significantly lower in eyes with compared to those without CMvD. Multivariable linear regression analyses indicated that a lower inferotemporal ONH-VD was independently associated with CMvD presence and a greater CMvD angular extent (both P < 0.05). The localized presence of parapapillary CMvD in OAG eyes is significantly associated with ONH-VD loss in the neighboring ONH location, with a spatial correlation.
format	article
author	Min Kyung Song Joong Won Shin Jin Yeong Lee Ji Wook Hong Michael S. Kook
author_facet	Min Kyung Song Joong Won Shin Jin Yeong Lee Ji Wook Hong Michael S. Kook
author_sort	Min Kyung Song
title	Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma
title_short	Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma
title_full	Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma
title_fullStr	Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma
title_full_unstemmed	Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma
title_sort	choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f6e62b7eec143ab842c441b591d28f1
work_keys_str_mv	AT minkyungsong choroidalmicrovasculaturedropoutisspatiallyassociatedwithopticnerveheadmicrovasculaturelossinopenangleglaucoma AT joongwonshin choroidalmicrovasculaturedropoutisspatiallyassociatedwithopticnerveheadmicrovasculaturelossinopenangleglaucoma AT jinyeonglee choroidalmicrovasculaturedropoutisspatiallyassociatedwithopticnerveheadmicrovasculaturelossinopenangleglaucoma AT jiwookhong choroidalmicrovasculaturedropoutisspatiallyassociatedwithopticnerveheadmicrovasculaturelossinopenangleglaucoma AT michaelskook choroidalmicrovasculaturedropoutisspatiallyassociatedwithopticnerveheadmicrovasculaturelossinopenangleglaucoma
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Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma

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