Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction

Abstract Asthma is a complex disease that is reportedly associated with insomnia. However, the causal directionality of this association is still unclear. We used asthma and insomnia-associated single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) summary statistics to test...

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Autores principales:	Dong Jun Kim, Tae-Woong Ha, Hae Un Jung, Eun Ju Baek, Won Jun Lee, Han Kyul Kim, Ji-One Kang, Sungho Won, Ji Eun Lim, Bermseok Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f6ee38ff9fb4439bc8102b727974bdb
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spelling	oai:doaj.org-article:6f6ee38ff9fb4439bc8102b727974bdb2021-11-14T12:22:07ZCharacterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction10.1038/s41598-021-01291-62045-2322https://doaj.org/article/6f6ee38ff9fb4439bc8102b727974bdb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01291-6https://doaj.org/toc/2045-2322Abstract Asthma is a complex disease that is reportedly associated with insomnia. However, the causal directionality of this association is still unclear. We used asthma and insomnia-associated single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) summary statistics to test the causal directionality between insomnia and asthma via Mendelian randomization (MR) analysis. We also performed a cross-trait meta-analysis using UK Biobank GWAS summary statistics and a gene–environment interaction study using data from UK Biobank. The interaction of genetic risk score for asthma (GRSasthma) with insomnia on asthma was tested by logistic regression. Insomnia was a risk factor for the incidence of asthma, as revealed by three different methods of MR analysis. However, asthma did not act as a risk factor for insomnia. The cross-trait meta-analysis identified 28 genetic loci shared between asthma and insomnia. In the gene–environment interaction study, GRSasthma interacted with insomnia to significantly affect the risk of asthma. The results of this study highlight the importance of insomnia as a risk factor of asthma, and warrant further analysis of the mechanism through which insomnia affects the risk of asthma.Dong Jun KimTae-Woong HaHae Un JungEun Ju BaekWon Jun LeeHan Kyul KimJi-One KangSungho WonJi Eun LimBermseok OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Jun Kim Tae-Woong Ha Hae Un Jung Eun Ju Baek Won Jun Lee Han Kyul Kim Ji-One Kang Sungho Won Ji Eun Lim Bermseok Oh Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction
description	Abstract Asthma is a complex disease that is reportedly associated with insomnia. However, the causal directionality of this association is still unclear. We used asthma and insomnia-associated single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) summary statistics to test the causal directionality between insomnia and asthma via Mendelian randomization (MR) analysis. We also performed a cross-trait meta-analysis using UK Biobank GWAS summary statistics and a gene–environment interaction study using data from UK Biobank. The interaction of genetic risk score for asthma (GRSasthma) with insomnia on asthma was tested by logistic regression. Insomnia was a risk factor for the incidence of asthma, as revealed by three different methods of MR analysis. However, asthma did not act as a risk factor for insomnia. The cross-trait meta-analysis identified 28 genetic loci shared between asthma and insomnia. In the gene–environment interaction study, GRSasthma interacted with insomnia to significantly affect the risk of asthma. The results of this study highlight the importance of insomnia as a risk factor of asthma, and warrant further analysis of the mechanism through which insomnia affects the risk of asthma.
format	article
author	Dong Jun Kim Tae-Woong Ha Hae Un Jung Eun Ju Baek Won Jun Lee Han Kyul Kim Ji-One Kang Sungho Won Ji Eun Lim Bermseok Oh
author_facet	Dong Jun Kim Tae-Woong Ha Hae Un Jung Eun Ju Baek Won Jun Lee Han Kyul Kim Ji-One Kang Sungho Won Ji Eun Lim Bermseok Oh
author_sort	Dong Jun Kim
title	Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction
title_short	Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction
title_full	Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction
title_fullStr	Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction
title_full_unstemmed	Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction
title_sort	characterisation of insomnia as an environmental risk factor for asthma via mendelian randomization and gene environment interaction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f6ee38ff9fb4439bc8102b727974bdb
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Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction

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