Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody responses in animals with a human Ig repertoire.

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Autores principales:	Ralph Pantophlet, Nino Trattnig, Sasha Murrell, Naiomi Lu, Dennis Chau, Caitlin Rempel, Ian A. Wilson, Paul Kosma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f723175653248f8b81328e5c6e0e922
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spelling	oai:doaj.org-article:6f723175653248f8b81328e5c6e0e9222021-12-02T14:41:10ZBacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity10.1038/s41467-017-01640-y2041-1723https://doaj.org/article/6f723175653248f8b81328e5c6e0e9222017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01640-yhttps://doaj.org/toc/2041-1723Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody responses in animals with a human Ig repertoire.Ralph PantophletNino TrattnigSasha MurrellNaiomi LuDennis ChauCaitlin RempelIan A. WilsonPaul KosmaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ralph Pantophlet Nino Trattnig Sasha Murrell Naiomi Lu Dennis Chau Caitlin Rempel Ian A. Wilson Paul Kosma Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
description	Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody responses in animals with a human Ig repertoire.
format	article
author	Ralph Pantophlet Nino Trattnig Sasha Murrell Naiomi Lu Dennis Chau Caitlin Rempel Ian A. Wilson Paul Kosma
author_facet	Ralph Pantophlet Nino Trattnig Sasha Murrell Naiomi Lu Dennis Chau Caitlin Rempel Ian A. Wilson Paul Kosma
author_sort	Ralph Pantophlet
title	Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
title_short	Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
title_full	Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
title_fullStr	Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
title_full_unstemmed	Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
title_sort	bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize hiv infectivity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6f723175653248f8b81328e5c6e0e922
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Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

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