Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial

Abstract Background Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged m...

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Autores principales:	Siv K. Bøhn, Mari C. W. Myhrstad, Magne Thoresen, Iris Erlund, Ann Kristin Vasstrand, Anne Marciuch, Monica H. Carlsen, Nasser E. Bastani, Knut Engedal, Kjell M. Flekkøy, Rune Blomhoff
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Bilberry; blueberry; blueberries Grape Cytokines Memory Inflammation Aged men Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6f7334a9fb0642219ac8cf5dcf9c894f
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spelling	oai:doaj.org-article:6f7334a9fb0642219ac8cf5dcf9c894f2021-11-28T12:13:50ZBilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial10.1186/s40795-021-00482-82055-0928https://doaj.org/article/6f7334a9fb0642219ac8cf5dcf9c894f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40795-021-00482-8https://doaj.org/toc/2055-0928Abstract Background Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment. Methods Nine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention. Results Compared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]). Conclusions The results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established. Trial registration Registration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009.Siv K. BøhnMari C. W. MyhrstadMagne ThoresenIris ErlundAnn Kristin VasstrandAnne MarciuchMonica H. CarlsenNasser E. BastaniKnut EngedalKjell M. FlekkøyRune BlomhoffBMCarticleBilberry; blueberry; blueberriesGrapeCytokinesMemoryInflammationAged menNutrition. Foods and food supplyTX341-641Food processing and manufactureTP368-456Medicine (General)R5-920ENBMC Nutrition, Vol 7, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bilberry; blueberry; blueberries Grape Cytokines Memory Inflammation Aged men Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Medicine (General) R5-920
spellingShingle	Bilberry; blueberry; blueberries Grape Cytokines Memory Inflammation Aged men Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Medicine (General) R5-920 Siv K. Bøhn Mari C. W. Myhrstad Magne Thoresen Iris Erlund Ann Kristin Vasstrand Anne Marciuch Monica H. Carlsen Nasser E. Bastani Knut Engedal Kjell M. Flekkøy Rune Blomhoff Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
description	Abstract Background Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment. Methods Nine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention. Results Compared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]). Conclusions The results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established. Trial registration Registration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009.
format	article
author	Siv K. Bøhn Mari C. W. Myhrstad Magne Thoresen Iris Erlund Ann Kristin Vasstrand Anne Marciuch Monica H. Carlsen Nasser E. Bastani Knut Engedal Kjell M. Flekkøy Rune Blomhoff
author_facet	Siv K. Bøhn Mari C. W. Myhrstad Magne Thoresen Iris Erlund Ann Kristin Vasstrand Anne Marciuch Monica H. Carlsen Nasser E. Bastani Knut Engedal Kjell M. Flekkøy Rune Blomhoff
author_sort	Siv K. Bøhn
title	Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
title_short	Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
title_full	Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
title_fullStr	Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
title_full_unstemmed	Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
title_sort	bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6f7334a9fb0642219ac8cf5dcf9c894f
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Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial

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