Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis

Abstract This study was conducted to investigate epigenetic landscape across multiple species and identify transcription factors (TFs) and their roles in controlling cell fate decision events during early embryogenesis. We made a comprehensively joint-research of chromatin accessibility of five spec...

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Autores principales:	Tongqiang Fan, Youjun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f744070a8e64136af2856c3ff40cfed
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spelling	oai:doaj.org-article:6f744070a8e64136af2856c3ff40cfed2021-12-02T14:26:16ZAccessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis10.1038/s41598-021-86919-32045-2322https://doaj.org/article/6f744070a8e64136af2856c3ff40cfed2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86919-3https://doaj.org/toc/2045-2322Abstract This study was conducted to investigate epigenetic landscape across multiple species and identify transcription factors (TFs) and their roles in controlling cell fate decision events during early embryogenesis. We made a comprehensively joint-research of chromatin accessibility of five species during embryogenesis by integration of ATAC-seq and RNA-seq datasets. Regulatory roles of candidate early embryonic TFs were investigated. Widespread accessible chromatin in early embryos overlapped with putative cis-regulatory sequences. Sets of cell-fate-determining TFs were identified. YOX1, a key cell cycle regulator, were found to homologous to clusters of TFs that are involved in neuron and epidermal cell-fate determination. Our research provides an intriguing insight into evolution of cell-fate decision during early embryogenesis among organisms.Tongqiang FanYoujun HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tongqiang Fan Youjun Huang Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis
description	Abstract This study was conducted to investigate epigenetic landscape across multiple species and identify transcription factors (TFs) and their roles in controlling cell fate decision events during early embryogenesis. We made a comprehensively joint-research of chromatin accessibility of five species during embryogenesis by integration of ATAC-seq and RNA-seq datasets. Regulatory roles of candidate early embryonic TFs were investigated. Widespread accessible chromatin in early embryos overlapped with putative cis-regulatory sequences. Sets of cell-fate-determining TFs were identified. YOX1, a key cell cycle regulator, were found to homologous to clusters of TFs that are involved in neuron and epidermal cell-fate determination. Our research provides an intriguing insight into evolution of cell-fate decision during early embryogenesis among organisms.
format	article
author	Tongqiang Fan Youjun Huang
author_facet	Tongqiang Fan Youjun Huang
author_sort	Tongqiang Fan
title	Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis
title_short	Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis
title_full	Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis
title_fullStr	Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis
title_full_unstemmed	Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis
title_sort	accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f744070a8e64136af2856c3ff40cfed
work_keys_str_mv	AT tongqiangfan accessiblechromatinrevealsregulatorymechanismsunderlyingcellfatedecisionsduringearlyembryogenesis AT youjunhuang accessiblechromatinrevealsregulatorymechanismsunderlyingcellfatedecisionsduringearlyembryogenesis
_version_	1718391374230847488

Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis

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