Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China

Background and objects: The study aimed to evaluate the long-term neurological sequelae and the disease burden of JE in Gansu, China. Methods: JE patients were included as study population from 2005–2011 in Gansu, and a follow-up survey was conducted in 2007–2014. Pair-matched healthy individuals we...

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Autores principales:	Xuxia Wang, Li Su, Shougang Sun, Wenbiao Hu, Qiuling Mu, Xuefeng Liang, Na Jin, Tian Dai, Hui Li, Guihua Zhuang
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2021
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/6f74f11c8e494918887c8befdac09a07
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spelling	oai:doaj.org-article:6f74f11c8e494918887c8befdac09a072021-11-08T08:04:51ZLong-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China2214-999610.5334/aogh.3343https://doaj.org/article/6f74f11c8e494918887c8befdac09a072021-10-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/3343https://doaj.org/toc/2214-9996Background and objects: The study aimed to evaluate the long-term neurological sequelae and the disease burden of JE in Gansu, China. Methods: JE patients were included as study population from 2005–2011 in Gansu, and a follow-up survey was conducted in 2007–2014. Pair-matched healthy individuals were selected as controls. All subjects underwent a neurological examination and intelligence quotient (IQ) and memory quotient (MQ) assessments. Then, the disability-adjusted life years (DALYs), and direct and indirect medical expenses were systematic assessed. Results: Forty-four point seven percent of the JE patients had objective neurological deficits, compared with 2.4% of controls. Subnormal intelligence was found in 21.2% of JE subjects, compared with 1.2% control who exhibited a mildly reduced IQ. Abnormal MQ scores were noted in 56.3% JE subjects, compared with only 12.7% controls. Prevalence of each sequelae caused by JE were significantly higher in adults than in younger subjects. Furthermore, median DALY lost due to JE was 9.2 per subject. Median economic cost of JE was approximately $2776.6 per subject and significantly higher in adults than in younger subjects. Findings and Conclusions: JE patients suffered from severe neurological sequelae and high disease burden, resulting in a significant downstream burden for both the patients (especially adults) and the healthcare system.Xuxia WangLi SuShougang SunWenbiao HuQiuling MuXuefeng LiangNa JinTian DaiHui LiGuihua ZhuangUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 87, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Xuxia Wang Li Su Shougang Sun Wenbiao Hu Qiuling Mu Xuefeng Liang Na Jin Tian Dai Hui Li Guihua Zhuang Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China
description	Background and objects: The study aimed to evaluate the long-term neurological sequelae and the disease burden of JE in Gansu, China. Methods: JE patients were included as study population from 2005–2011 in Gansu, and a follow-up survey was conducted in 2007–2014. Pair-matched healthy individuals were selected as controls. All subjects underwent a neurological examination and intelligence quotient (IQ) and memory quotient (MQ) assessments. Then, the disability-adjusted life years (DALYs), and direct and indirect medical expenses were systematic assessed. Results: Forty-four point seven percent of the JE patients had objective neurological deficits, compared with 2.4% of controls. Subnormal intelligence was found in 21.2% of JE subjects, compared with 1.2% control who exhibited a mildly reduced IQ. Abnormal MQ scores were noted in 56.3% JE subjects, compared with only 12.7% controls. Prevalence of each sequelae caused by JE were significantly higher in adults than in younger subjects. Furthermore, median DALY lost due to JE was 9.2 per subject. Median economic cost of JE was approximately $2776.6 per subject and significantly higher in adults than in younger subjects. Findings and Conclusions: JE patients suffered from severe neurological sequelae and high disease burden, resulting in a significant downstream burden for both the patients (especially adults) and the healthcare system.
format	article
author	Xuxia Wang Li Su Shougang Sun Wenbiao Hu Qiuling Mu Xuefeng Liang Na Jin Tian Dai Hui Li Guihua Zhuang
author_facet	Xuxia Wang Li Su Shougang Sun Wenbiao Hu Qiuling Mu Xuefeng Liang Na Jin Tian Dai Hui Li Guihua Zhuang
author_sort	Xuxia Wang
title	Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China
title_short	Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China
title_full	Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China
title_fullStr	Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China
title_full_unstemmed	Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China
title_sort	long-term neurological sequelae and disease burden of japanese encephalitis in gansu province, china
publisher	Ubiquity Press
publishDate	2021
url	https://doaj.org/article/6f74f11c8e494918887c8befdac09a07
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Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China

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