Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegener...

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Autores principales:	João Duarte Magalhães, Lígia Fão, Rita Vilaça, Sandra Morais Cardoso, Ana Cristina Rego
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neurodegenerative disorders autophagy mitophagy mitochondrial dysfunction mutant proteins therapeutic strategies Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6f78b7975de548c9ac8d1c282986a06e
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spelling	oai:doaj.org-article:6f78b7975de548c9ac8d1c282986a06e2021-11-25T16:49:44ZMacroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions10.3390/biomedicines91116252227-9059https://doaj.org/article/6f78b7975de548c9ac8d1c282986a06e2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1625https://doaj.org/toc/2227-9059Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunction in the etiology of Alzheimer’s, Parkinson’s, and Huntington’s diseases. Macroautophagy has been implicated in the degradation of different protein aggregates such as Aβ, tau, alpha-synuclein (α-syn), and mutant huntingtin (mHtt) and in the clearance of dysfunctional mitochondria. Taking these into consideration, targeting autophagy might represent an effective therapeutic strategy to eliminate protein aggregates and to improve mitochondrial function in these disorders. The present review describes our current understanding on the role of macroautophagy in neurodegenerative disorders and focuses on possible strategies for its therapeutic modulation.João Duarte MagalhãesLígia FãoRita VilaçaSandra Morais CardosoAna Cristina RegoMDPI AGarticleneurodegenerative disordersautophagymitophagy mitochondrial dysfunctionmutant proteinstherapeutic strategiesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1625, p 1625 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurodegenerative disorders autophagy mitophagy mitochondrial dysfunction mutant proteins therapeutic strategies Biology (General) QH301-705.5
spellingShingle	neurodegenerative disorders autophagy mitophagy mitochondrial dysfunction mutant proteins therapeutic strategies Biology (General) QH301-705.5 João Duarte Magalhães Lígia Fão Rita Vilaça Sandra Morais Cardoso Ana Cristina Rego Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
description	Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunction in the etiology of Alzheimer’s, Parkinson’s, and Huntington’s diseases. Macroautophagy has been implicated in the degradation of different protein aggregates such as Aβ, tau, alpha-synuclein (α-syn), and mutant huntingtin (mHtt) and in the clearance of dysfunctional mitochondria. Taking these into consideration, targeting autophagy might represent an effective therapeutic strategy to eliminate protein aggregates and to improve mitochondrial function in these disorders. The present review describes our current understanding on the role of macroautophagy in neurodegenerative disorders and focuses on possible strategies for its therapeutic modulation.
format	article
author	João Duarte Magalhães Lígia Fão Rita Vilaça Sandra Morais Cardoso Ana Cristina Rego
author_facet	João Duarte Magalhães Lígia Fão Rita Vilaça Sandra Morais Cardoso Ana Cristina Rego
author_sort	João Duarte Magalhães
title	Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
title_short	Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
title_full	Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
title_fullStr	Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
title_full_unstemmed	Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
title_sort	macroautophagy and mitophagy in neurodegenerative disorders: focus on therapeutic interventions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f78b7975de548c9ac8d1c282986a06e
work_keys_str_mv	AT joaoduartemagalhaes macroautophagyandmitophagyinneurodegenerativedisordersfocusontherapeuticinterventions AT ligiafao macroautophagyandmitophagyinneurodegenerativedisordersfocusontherapeuticinterventions AT ritavilaca macroautophagyandmitophagyinneurodegenerativedisordersfocusontherapeuticinterventions AT sandramoraiscardoso macroautophagyandmitophagyinneurodegenerativedisordersfocusontherapeuticinterventions AT anacristinarego macroautophagyandmitophagyinneurodegenerativedisordersfocusontherapeuticinterventions
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Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

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