MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state
Breast cancer tumors originating from mammary luminal epithelial cells are highly heterogeneous. Here, the authors show MYC-driven tumor initiation is reliant on cell reprogramming via an epigenetic program which leads to mammary luminal epithelial cells acquiring basal/stem cell-like properties.
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Nature Portfolio
2018
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oai:doaj.org-article:6f7aa572016b47c0baed8f32cb07716f2021-12-02T14:41:05ZMYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state10.1038/s41467-018-03264-22041-1723https://doaj.org/article/6f7aa572016b47c0baed8f32cb07716f2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03264-2https://doaj.org/toc/2041-1723Breast cancer tumors originating from mammary luminal epithelial cells are highly heterogeneous. Here, the authors show MYC-driven tumor initiation is reliant on cell reprogramming via an epigenetic program which leads to mammary luminal epithelial cells acquiring basal/stem cell-like properties.Vittoria PoliLuca FagnocchiAlessandra FascianiAlessandro CherubiniStefania MazzoleniSara FerrilloAnnarita MiluzioGabriella GaudiosoValentina VairaAlice TurdoMiriam GaggianesiAurora ChinniciElisa LipariSilvio BicciatoSilvano BosariMatilde TodaroAlessio ZippoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Vittoria Poli Luca Fagnocchi Alessandra Fasciani Alessandro Cherubini Stefania Mazzoleni Sara Ferrillo Annarita Miluzio Gabriella Gaudioso Valentina Vaira Alice Turdo Miriam Gaggianesi Aurora Chinnici Elisa Lipari Silvio Bicciato Silvano Bosari Matilde Todaro Alessio Zippo MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state |
| description |
Breast cancer tumors originating from mammary luminal epithelial cells are highly heterogeneous. Here, the authors show MYC-driven tumor initiation is reliant on cell reprogramming via an epigenetic program which leads to mammary luminal epithelial cells acquiring basal/stem cell-like properties. |
| format |
article |
| author |
Vittoria Poli Luca Fagnocchi Alessandra Fasciani Alessandro Cherubini Stefania Mazzoleni Sara Ferrillo Annarita Miluzio Gabriella Gaudioso Valentina Vaira Alice Turdo Miriam Gaggianesi Aurora Chinnici Elisa Lipari Silvio Bicciato Silvano Bosari Matilde Todaro Alessio Zippo |
| author_facet |
Vittoria Poli Luca Fagnocchi Alessandra Fasciani Alessandro Cherubini Stefania Mazzoleni Sara Ferrillo Annarita Miluzio Gabriella Gaudioso Valentina Vaira Alice Turdo Miriam Gaggianesi Aurora Chinnici Elisa Lipari Silvio Bicciato Silvano Bosari Matilde Todaro Alessio Zippo |
| author_sort |
Vittoria Poli |
| title |
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state |
| title_short |
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state |
| title_full |
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state |
| title_fullStr |
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state |
| title_full_unstemmed |
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state |
| title_sort |
myc-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/6f7aa572016b47c0baed8f32cb07716f |
| work_keys_str_mv |
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