Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns

Transcription factors Distal-less(Dll) and spalt were co-opted during the evolution of butterfly eyespots. Here, Zhang and Reed use CRISPR/Cas9 genome editing to show that while spalt is a positive regulator of eyespots as predicted, Dll knockouts have positive effects on both eyespot size and numbe...

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Autores principales:	Linlin Zhang, Robert D. Reed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f809259ef6d46ec843d009355707cbc
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spelling	oai:doaj.org-article:6f809259ef6d46ec843d009355707cbc2021-12-02T16:57:00ZGenome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns10.1038/ncomms117692041-1723https://doaj.org/article/6f809259ef6d46ec843d009355707cbc2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11769https://doaj.org/toc/2041-1723Transcription factors Distal-less(Dll) and spalt were co-opted during the evolution of butterfly eyespots. Here, Zhang and Reed use CRISPR/Cas9 genome editing to show that while spalt is a positive regulator of eyespots as predicted, Dll knockouts have positive effects on both eyespot size and number, thus suggesting that Dllis an eyespot repressor, not an activator as previously thought.Linlin ZhangRobert D. ReedNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linlin Zhang Robert D. Reed Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns
description	Transcription factors Distal-less(Dll) and spalt were co-opted during the evolution of butterfly eyespots. Here, Zhang and Reed use CRISPR/Cas9 genome editing to show that while spalt is a positive regulator of eyespots as predicted, Dll knockouts have positive effects on both eyespot size and number, thus suggesting that Dllis an eyespot repressor, not an activator as previously thought.
format	article
author	Linlin Zhang Robert D. Reed
author_facet	Linlin Zhang Robert D. Reed
author_sort	Linlin Zhang
title	Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns
title_short	Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns
title_full	Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns
title_fullStr	Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns
title_full_unstemmed	Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns
title_sort	genome editing in butterflies reveals that spalt promotes and distal-less represses eyespot colour patterns
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6f809259ef6d46ec843d009355707cbc
work_keys_str_mv	AT linlinzhang genomeeditinginbutterfliesrevealsthatspaltpromotesanddistallessrepresseseyespotcolourpatterns AT robertdreed genomeeditinginbutterfliesrevealsthatspaltpromotesanddistallessrepresseseyespotcolourpatterns
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Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns

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