Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex

Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We ad...

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Autores principales:	P Christiaan Klink, Xing Chen, Wim Vanduffel, Pieter R Roelfsema
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	population receptive field vision nonhuman primate neuroimaging neurophysiology Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6f80c614e6e442c0ad44939f57f41a2a
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spelling	oai:doaj.org-article:6f80c614e6e442c0ad44939f57f41a2a2021-12-03T11:45:28ZPopulation receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex10.7554/eLife.673042050-084Xe67304https://doaj.org/article/6f80c614e6e442c0ad44939f57f41a2a2021-11-01T00:00:00Zhttps://elifesciences.org/articles/67304https://doaj.org/toc/2050-084XPopulation receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake nonhuman primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF models based on the fMRI blood-oxygen-level-dependent (BOLD) signal, multi-unit spiking activity (MUA), and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. fMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF size with increasing eccentricity, as well as a retinotopically specific deactivation of default mode network nodes similar to previous observations in humans.P Christiaan KlinkXing ChenWim VanduffelPieter R RoelfsemaeLife Sciences Publications Ltdarticlepopulation receptive fieldvisionnonhuman primateneuroimagingneurophysiologyMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	population receptive field vision nonhuman primate neuroimaging neurophysiology Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	population receptive field vision nonhuman primate neuroimaging neurophysiology Medicine R Science Q Biology (General) QH301-705.5 P Christiaan Klink Xing Chen Wim Vanduffel Pieter R Roelfsema Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
description	Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake nonhuman primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF models based on the fMRI blood-oxygen-level-dependent (BOLD) signal, multi-unit spiking activity (MUA), and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. fMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF size with increasing eccentricity, as well as a retinotopically specific deactivation of default mode network nodes similar to previous observations in humans.
format	article
author	P Christiaan Klink Xing Chen Wim Vanduffel Pieter R Roelfsema
author_facet	P Christiaan Klink Xing Chen Wim Vanduffel Pieter R Roelfsema
author_sort	P Christiaan Klink
title	Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
title_short	Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
title_full	Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
title_fullStr	Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
title_full_unstemmed	Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex
title_sort	population receptive fields in nonhuman primates from whole-brain fmri and large-scale neurophysiology in visual cortex
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/6f80c614e6e442c0ad44939f57f41a2a
work_keys_str_mv	AT pchristiaanklink populationreceptivefieldsinnonhumanprimatesfromwholebrainfmriandlargescaleneurophysiologyinvisualcortex AT xingchen populationreceptivefieldsinnonhumanprimatesfromwholebrainfmriandlargescaleneurophysiologyinvisualcortex AT wimvanduffel populationreceptivefieldsinnonhumanprimatesfromwholebrainfmriandlargescaleneurophysiologyinvisualcortex AT pieterrroelfsema populationreceptivefieldsinnonhumanprimatesfromwholebrainfmriandlargescaleneurophysiologyinvisualcortex
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Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex

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