Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer

Background: Prostate specific membrane antigen (PSMA) positron emission tomography computed tomography (PET-CT) and whole-body magnetic resonance imaging (WB-MRI) outperform standard imaging technology for the detection of metastasis in prostate cancer (PCa). There are few direct comparisons between...

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Autores principales:	Julien Van Damme, Bertrand Tombal, Laurence Collette, Sandy Van Nieuwenhove, Vassiliki Pasoglou, Thomas Gérard, François Jamar, Renaud Lhommel, Frédéric E. Lecouvet
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	PSMA PET-CT WB-MRI prostate cancer staging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6f81edad118f49f797a77c2151d0d1f8
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spelling	oai:doaj.org-article:6f81edad118f49f797a77c2151d0d1f82021-11-11T15:27:11ZComparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer10.3390/cancers132152862072-6694https://doaj.org/article/6f81edad118f49f797a77c2151d0d1f82021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5286https://doaj.org/toc/2072-6694Background: Prostate specific membrane antigen (PSMA) positron emission tomography computed tomography (PET-CT) and whole-body magnetic resonance imaging (WB-MRI) outperform standard imaging technology for the detection of metastasis in prostate cancer (PCa). There are few direct comparisons between both modalities. This paper compares the diagnostic accuracy of PSMA PET-CT and WB-MRI for the detection of metastasis in PCa. One hundred thirty-four patients with newly diagnosed PCa (<i>n</i> = 81) or biochemical recurrence after curative treatment (<i>n</i> = 53) with high-risk features prospectively underwent PSMA PET-CT and WB-MRI. The diagnostic accuracy of both techniques for lymph node, skeletal and visceral metastases was compared against a best valuable comparator (BVC). Overall, no significant difference was detected between PSMA PET-CT and WB-MRI to identify metastatic patients when considering lymph nodes, skeletal and visceral metastases together (AUC = 0.96 (0.92–0.99) vs. 0.90 (0.85–0.95); <i>p</i> = 0.09). PSMA PET-CT, however, outperformed WB-MRI in the subgroup of patients with newly diagnosed PCa for the detection of lymph node metastases (AUC = 0.96 (0.92–0.99) vs. 0.86 (0.79–0.92); <i>p</i> = 0.0096). In conclusion, PSMA PET-CT outperforms WB-MRI for the detection of nodal metastases in primary staging of PCa.Julien Van DammeBertrand TombalLaurence ColletteSandy Van NieuwenhoveVassiliki PasoglouThomas GérardFrançois JamarRenaud LhommelFrédéric E. LecouvetMDPI AGarticlePSMAPET-CTWB-MRIprostate cancerstagingNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5286, p 5286 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PSMA PET-CT WB-MRI prostate cancer staging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	PSMA PET-CT WB-MRI prostate cancer staging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Julien Van Damme Bertrand Tombal Laurence Collette Sandy Van Nieuwenhove Vassiliki Pasoglou Thomas Gérard François Jamar Renaud Lhommel Frédéric E. Lecouvet Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer
description	Background: Prostate specific membrane antigen (PSMA) positron emission tomography computed tomography (PET-CT) and whole-body magnetic resonance imaging (WB-MRI) outperform standard imaging technology for the detection of metastasis in prostate cancer (PCa). There are few direct comparisons between both modalities. This paper compares the diagnostic accuracy of PSMA PET-CT and WB-MRI for the detection of metastasis in PCa. One hundred thirty-four patients with newly diagnosed PCa (<i>n</i> = 81) or biochemical recurrence after curative treatment (<i>n</i> = 53) with high-risk features prospectively underwent PSMA PET-CT and WB-MRI. The diagnostic accuracy of both techniques for lymph node, skeletal and visceral metastases was compared against a best valuable comparator (BVC). Overall, no significant difference was detected between PSMA PET-CT and WB-MRI to identify metastatic patients when considering lymph nodes, skeletal and visceral metastases together (AUC = 0.96 (0.92–0.99) vs. 0.90 (0.85–0.95); <i>p</i> = 0.09). PSMA PET-CT, however, outperformed WB-MRI in the subgroup of patients with newly diagnosed PCa for the detection of lymph node metastases (AUC = 0.96 (0.92–0.99) vs. 0.86 (0.79–0.92); <i>p</i> = 0.0096). In conclusion, PSMA PET-CT outperforms WB-MRI for the detection of nodal metastases in primary staging of PCa.
format	article
author	Julien Van Damme Bertrand Tombal Laurence Collette Sandy Van Nieuwenhove Vassiliki Pasoglou Thomas Gérard François Jamar Renaud Lhommel Frédéric E. Lecouvet
author_facet	Julien Van Damme Bertrand Tombal Laurence Collette Sandy Van Nieuwenhove Vassiliki Pasoglou Thomas Gérard François Jamar Renaud Lhommel Frédéric E. Lecouvet
author_sort	Julien Van Damme
title	Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer
title_short	Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer
title_full	Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer
title_fullStr	Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer
title_full_unstemmed	Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer
title_sort	comparison of <sup>68</sup>ga-prostate specific membrane antigen (psma) positron emission tomography computed tomography (pet-ct) and whole-body magnetic resonance imaging (wb-mri) with diffusion sequences (dwi) in the staging of advanced prostate cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f81edad118f49f797a77c2151d0d1f8
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Comparison of <sup>68</sup>Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography Computed Tomography (PET-CT) and Whole-Body Magnetic Resonance Imaging (WB-MRI) with Diffusion Sequences (DWI) in the Staging of Advanced Prostate Cancer

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