Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limits Notch1-induced differentiation, permitting Notch...

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Autores principales:	Mitsuteru Natsuizaka, Kelly A. Whelan, Shingo Kagawa, Koji Tanaka, Veronique Giroux, Prasanna M. Chandramouleeswaran, Apple Long, Varun Sahu, Douglas S. Darling, Jianwen Que, Yizeng Yang, Jonathan P. Katz, E. Paul Wileyto, Devraj Basu, Yoshiaki Kita, Shoji Natsugoe, Seiji Naganuma, Andres J. Klein-Szanto, J. Alan Diehl, Adam J. Bass, Kwok-Kin Wong, Anil K. Rustgi, Hiroshi Nakagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f8691ad6d324ab0a967f60181be89c5
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spelling	oai:doaj.org-article:6f8691ad6d324ab0a967f60181be89c52021-12-02T17:06:17ZInterplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma10.1038/s41467-017-01500-92041-1723https://doaj.org/article/6f8691ad6d324ab0a967f60181be89c52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01500-9https://doaj.org/toc/2041-1723Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limits Notch1-induced differentiation, permitting Notch1-mediated EMT.Mitsuteru NatsuizakaKelly A. WhelanShingo KagawaKoji TanakaVeronique GirouxPrasanna M. ChandramouleeswaranApple LongVarun SahuDouglas S. DarlingJianwen QueYizeng YangJonathan P. KatzE. Paul WileytoDevraj BasuYoshiaki KitaShoji NatsugoeSeiji NaganumaAndres J. Klein-SzantoJ. Alan DiehlAdam J. BassKwok-Kin WongAnil K. RustgiHiroshi NakagawaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mitsuteru Natsuizaka Kelly A. Whelan Shingo Kagawa Koji Tanaka Veronique Giroux Prasanna M. Chandramouleeswaran Apple Long Varun Sahu Douglas S. Darling Jianwen Que Yizeng Yang Jonathan P. Katz E. Paul Wileyto Devraj Basu Yoshiaki Kita Shoji Natsugoe Seiji Naganuma Andres J. Klein-Szanto J. Alan Diehl Adam J. Bass Kwok-Kin Wong Anil K. Rustgi Hiroshi Nakagawa Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
description	Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limits Notch1-induced differentiation, permitting Notch1-mediated EMT.
format	article
author	Mitsuteru Natsuizaka Kelly A. Whelan Shingo Kagawa Koji Tanaka Veronique Giroux Prasanna M. Chandramouleeswaran Apple Long Varun Sahu Douglas S. Darling Jianwen Que Yizeng Yang Jonathan P. Katz E. Paul Wileyto Devraj Basu Yoshiaki Kita Shoji Natsugoe Seiji Naganuma Andres J. Klein-Szanto J. Alan Diehl Adam J. Bass Kwok-Kin Wong Anil K. Rustgi Hiroshi Nakagawa
author_facet	Mitsuteru Natsuizaka Kelly A. Whelan Shingo Kagawa Koji Tanaka Veronique Giroux Prasanna M. Chandramouleeswaran Apple Long Varun Sahu Douglas S. Darling Jianwen Que Yizeng Yang Jonathan P. Katz E. Paul Wileyto Devraj Basu Yoshiaki Kita Shoji Natsugoe Seiji Naganuma Andres J. Klein-Szanto J. Alan Diehl Adam J. Bass Kwok-Kin Wong Anil K. Rustgi Hiroshi Nakagawa
author_sort	Mitsuteru Natsuizaka
title	Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
title_short	Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
title_full	Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
title_fullStr	Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
title_full_unstemmed	Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
title_sort	interplay between notch1 and notch3 promotes emt and tumor initiation in squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6f8691ad6d324ab0a967f60181be89c5
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Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

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