The Role of Long Non-Coding RNAs in Endometriosis

Endometriosis is a chronic gynecological disorder affecting the quality of life and fertility of many women around the world. Heterogeneous and non-specific symptoms may lead to a delay in diagnosis, with treatment options limited to surgery and hormonal therapy. Hence, there is a need to better und...

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Autores principales:	Quanah J. Hudson, Katharina Proestling, Alexandra Perricos, Lorenz Kuessel, Heinrich Husslein, René Wenzl, Iveta Yotova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endometriosis long non-coding RNAs lncRNAs sponging ceRNA chromatin Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6f879c44c7514a8084bd988a8c542e9c
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spelling	oai:doaj.org-article:6f879c44c7514a8084bd988a8c542e9c2021-11-11T16:53:46ZThe Role of Long Non-Coding RNAs in Endometriosis10.3390/ijms2221114251422-00671661-6596https://doaj.org/article/6f879c44c7514a8084bd988a8c542e9c2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11425https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Endometriosis is a chronic gynecological disorder affecting the quality of life and fertility of many women around the world. Heterogeneous and non-specific symptoms may lead to a delay in diagnosis, with treatment options limited to surgery and hormonal therapy. Hence, there is a need to better understand the pathogenesis of the disease to improve diagnosis and treatment. Long non-coding RNAs (lncRNAs) have been increasingly shown to be involved in gene regulation but remain relatively under investigated in endometriosis. Mutational and transcriptomic studies have implicated lncRNAs in the pathogenesis of endometriosis. Single-nucleotide polymorphisms (SNPs) in lncRNAs or their regulatory regions have been associated with endometriosis. Genome-wide transcriptomic studies have identified lncRNAs that show deregulated expression in endometriosis, some of which have been subjected to further experiments, which support a role in endometriosis. Mechanistic studies indicate that lncRNAs may regulate genes involved in endometriosis by acting as a molecular sponge for miRNAs, by directly targeting regulatory elements via interactions with chromatin or transcription factors or by affecting signaling pathways. Future studies should concentrate on determining the role of uncharacterized lncRNAs revealed by endometriosis transcriptome studies and the relevance of lncRNAs implicated in the disease by in vitro and animal model studies.Quanah J. HudsonKatharina ProestlingAlexandra PerricosLorenz KuesselHeinrich HussleinRené WenzlIveta YotovaMDPI AGarticleendometriosislong non-coding RNAslncRNAsspongingceRNAchromatinBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11425, p 11425 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endometriosis long non-coding RNAs lncRNAs sponging ceRNA chromatin Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	endometriosis long non-coding RNAs lncRNAs sponging ceRNA chromatin Biology (General) QH301-705.5 Chemistry QD1-999 Quanah J. Hudson Katharina Proestling Alexandra Perricos Lorenz Kuessel Heinrich Husslein René Wenzl Iveta Yotova The Role of Long Non-Coding RNAs in Endometriosis
description	Endometriosis is a chronic gynecological disorder affecting the quality of life and fertility of many women around the world. Heterogeneous and non-specific symptoms may lead to a delay in diagnosis, with treatment options limited to surgery and hormonal therapy. Hence, there is a need to better understand the pathogenesis of the disease to improve diagnosis and treatment. Long non-coding RNAs (lncRNAs) have been increasingly shown to be involved in gene regulation but remain relatively under investigated in endometriosis. Mutational and transcriptomic studies have implicated lncRNAs in the pathogenesis of endometriosis. Single-nucleotide polymorphisms (SNPs) in lncRNAs or their regulatory regions have been associated with endometriosis. Genome-wide transcriptomic studies have identified lncRNAs that show deregulated expression in endometriosis, some of which have been subjected to further experiments, which support a role in endometriosis. Mechanistic studies indicate that lncRNAs may regulate genes involved in endometriosis by acting as a molecular sponge for miRNAs, by directly targeting regulatory elements via interactions with chromatin or transcription factors or by affecting signaling pathways. Future studies should concentrate on determining the role of uncharacterized lncRNAs revealed by endometriosis transcriptome studies and the relevance of lncRNAs implicated in the disease by in vitro and animal model studies.
format	article
author	Quanah J. Hudson Katharina Proestling Alexandra Perricos Lorenz Kuessel Heinrich Husslein René Wenzl Iveta Yotova
author_facet	Quanah J. Hudson Katharina Proestling Alexandra Perricos Lorenz Kuessel Heinrich Husslein René Wenzl Iveta Yotova
author_sort	Quanah J. Hudson
title	The Role of Long Non-Coding RNAs in Endometriosis
title_short	The Role of Long Non-Coding RNAs in Endometriosis
title_full	The Role of Long Non-Coding RNAs in Endometriosis
title_fullStr	The Role of Long Non-Coding RNAs in Endometriosis
title_full_unstemmed	The Role of Long Non-Coding RNAs in Endometriosis
title_sort	role of long non-coding rnas in endometriosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6f879c44c7514a8084bd988a8c542e9c
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The Role of Long Non-Coding RNAs in Endometriosis

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