Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia.
Regulation of cytosolic calcium (Ca2+) dynamics is fundamental to microglial function. Temporal and spatial Ca2+ fluxes are induced from a complicated signal transduction pathway linked to brain ionic homeostasis. In this paper, we develop a novel biophysical model of Ca2+ and sodium (Na+) dynamics...
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Auteurs principaux: | Alireza Poshtkohi, John Wade, Liam McDaid, Junxiu Liu, Mark Dallas, Angela Bithell |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2021
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Accès en ligne: | https://doaj.org/article/6f8cfd3ec7944de7a9b5c4dbc9c4e45e |
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