A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy

von Hippel–Lindau (VHL) disease is an autosomal dominant hereditary disease with benign and malignant tumors occurring in various organs including the kidneys. In patients with renal cell carcinoma (RCC) lesions in both kidneys, it is difficult to determine the treatment strategy. We report a case o...

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Autores principales:	Takahiro Akioka, Naoki Terada, Hiroki Takamori, Toshio Kamimura, Shoichiro Mukai, Toshiyuki Kamoto
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Von hippel-lindau disease Renal cell carcinoma Partial nephrectomy Axitinib Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/6f8f277b09e1443ba50fb31ee89e8c46
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spelling	oai:doaj.org-article:6f8f277b09e1443ba50fb31ee89e8c462021-11-04T04:31:14ZA case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy2214-442010.1016/j.eucr.2021.101925https://doaj.org/article/6f8f277b09e1443ba50fb31ee89e8c462022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221444202100365Xhttps://doaj.org/toc/2214-4420von Hippel–Lindau (VHL) disease is an autosomal dominant hereditary disease with benign and malignant tumors occurring in various organs including the kidneys. In patients with renal cell carcinoma (RCC) lesions in both kidneys, it is difficult to determine the treatment strategy. We report a case of VHL disease with RCC treated via partial nephrectomy after 6 months of axitinib therapy. Then, the patient continued to receive low-dose axitinib therapy without any signs of tumor progression for 3 years after surgery. Axitinib combined with surgery might be a treatment option for patients with VHL disease harboring bilateral RCC.Takahiro AkiokaNaoki TeradaHiroki TakamoriToshio KamimuraShoichiro MukaiToshiyuki KamotoElsevierarticleVon hippel-lindau diseaseRenal cell carcinomaPartial nephrectomyAxitinibDiseases of the genitourinary system. UrologyRC870-923ENUrology Case Reports, Vol 40, Iss , Pp 101925- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Von hippel-lindau disease Renal cell carcinoma Partial nephrectomy Axitinib Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Von hippel-lindau disease Renal cell carcinoma Partial nephrectomy Axitinib Diseases of the genitourinary system. Urology RC870-923 Takahiro Akioka Naoki Terada Hiroki Takamori Toshio Kamimura Shoichiro Mukai Toshiyuki Kamoto A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy
description	von Hippel–Lindau (VHL) disease is an autosomal dominant hereditary disease with benign and malignant tumors occurring in various organs including the kidneys. In patients with renal cell carcinoma (RCC) lesions in both kidneys, it is difficult to determine the treatment strategy. We report a case of VHL disease with RCC treated via partial nephrectomy after 6 months of axitinib therapy. Then, the patient continued to receive low-dose axitinib therapy without any signs of tumor progression for 3 years after surgery. Axitinib combined with surgery might be a treatment option for patients with VHL disease harboring bilateral RCC.
format	article
author	Takahiro Akioka Naoki Terada Hiroki Takamori Toshio Kamimura Shoichiro Mukai Toshiyuki Kamoto
author_facet	Takahiro Akioka Naoki Terada Hiroki Takamori Toshio Kamimura Shoichiro Mukai Toshiyuki Kamoto
author_sort	Takahiro Akioka
title	A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy
title_short	A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy
title_full	A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy
title_fullStr	A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy
title_full_unstemmed	A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy
title_sort	case of von hippel–lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/6f8f277b09e1443ba50fb31ee89e8c46
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A case of von Hippel–Lindau disease with renal cell carcinoma treated by partial nephrectomy with pre- and post-surgical axitinib therapy

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