Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

Impairment of DNA repair has been associated with neurodegeneration. Here the authors investigate the mechanisms of defects in repair caused by mutations in the RNA/DNA binding protein FUS in amyotrophic lateral sclerosis and elucidate its role in the DNA ligation during DNA single-strand break repa...

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Autores principales:	Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Tijs Vandoorne, Bradley J. Eckelmann, Sankar Mitra, Alan E. Tomkinson, Ludo Van Den Bosch, Muralidhar L. Hegde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f901ba774c14e7094bb810d29ed252a
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spelling	oai:doaj.org-article:6f901ba774c14e7094bb810d29ed252a2021-12-02T16:49:56ZMutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis10.1038/s41467-018-06111-62041-1723https://doaj.org/article/6f901ba774c14e7094bb810d29ed252a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06111-6https://doaj.org/toc/2041-1723Impairment of DNA repair has been associated with neurodegeneration. Here the authors investigate the mechanisms of defects in repair caused by mutations in the RNA/DNA binding protein FUS in amyotrophic lateral sclerosis and elucidate its role in the DNA ligation during DNA single-strand break repair of oxidative breaks.Haibo WangWenting GuoJoy MitraPavana M. HegdeTijs VandoorneBradley J. EckelmannSankar MitraAlan E. TomkinsonLudo Van Den BoschMuralidhar L. HegdeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haibo Wang Wenting Guo Joy Mitra Pavana M. Hegde Tijs Vandoorne Bradley J. Eckelmann Sankar Mitra Alan E. Tomkinson Ludo Van Den Bosch Muralidhar L. Hegde Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
description	Impairment of DNA repair has been associated with neurodegeneration. Here the authors investigate the mechanisms of defects in repair caused by mutations in the RNA/DNA binding protein FUS in amyotrophic lateral sclerosis and elucidate its role in the DNA ligation during DNA single-strand break repair of oxidative breaks.
format	article
author	Haibo Wang Wenting Guo Joy Mitra Pavana M. Hegde Tijs Vandoorne Bradley J. Eckelmann Sankar Mitra Alan E. Tomkinson Ludo Van Den Bosch Muralidhar L. Hegde
author_facet	Haibo Wang Wenting Guo Joy Mitra Pavana M. Hegde Tijs Vandoorne Bradley J. Eckelmann Sankar Mitra Alan E. Tomkinson Ludo Van Den Bosch Muralidhar L. Hegde
author_sort	Haibo Wang
title	Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
title_short	Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
title_full	Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
title_fullStr	Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
title_full_unstemmed	Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
title_sort	mutant fus causes dna ligation defects to inhibit oxidative damage repair in amyotrophic lateral sclerosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6f901ba774c14e7094bb810d29ed252a
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Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

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