Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies

Abstract Evidence is emerging that paternal effects, the nongenetic influence of fathers on their offspring, can be transgenerational, spanning several generations. Methylphenidate hydrochloride (MPH; e.g. Ritalin) is a dopaminergic drug that is highly prescribed to adolescent males for the treatmen...

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Autores principales:	Alex R. De Serrano, Kimberly A. Hughes, F. Helen Rodd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6f94a0757b3746d184cf2761657e2482
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spelling	oai:doaj.org-article:6f94a0757b3746d184cf2761657e24822021-12-02T14:21:58ZPaternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies10.1038/s41598-021-83448-x2045-2322https://doaj.org/article/6f94a0757b3746d184cf2761657e24822021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83448-xhttps://doaj.org/toc/2045-2322Abstract Evidence is emerging that paternal effects, the nongenetic influence of fathers on their offspring, can be transgenerational, spanning several generations. Methylphenidate hydrochloride (MPH; e.g. Ritalin) is a dopaminergic drug that is highly prescribed to adolescent males for the treatment of Attention-deficit/hyperactivity disorder. It has been suggested that MPH could cause transgenerational effects because MPH can affect the male germline in rodents and because paternal effects have been observed in individuals taking similar drugs (e.g. cocaine). Despite these concerns, the transgenerational effects of paternal MPH exposure are unknown. Therefore, we exposed male and female Trinidadian guppies (Poecilia reticulata) to a low, chronic dose of MPH and observed that MPH affected the anxiety/exploratory behaviour of males, but not females. Because of this male-specific effect, we investigated the transgenerational effects of MPH through the paternal line. We observed behavioural effects of paternal MPH exposure on offspring and great-grandoffspring that were not directly administered the drug, making this the first study to demonstrate that paternal MPH exposure can affect descendants. These effects were not due to differential mortality or fecundity between control and MPH lines. These results highlight the transgenerational potential of MPH.Alex R. De SerranoKimberly A. HughesF. Helen RoddNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alex R. De Serrano Kimberly A. Hughes F. Helen Rodd Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies
description	Abstract Evidence is emerging that paternal effects, the nongenetic influence of fathers on their offspring, can be transgenerational, spanning several generations. Methylphenidate hydrochloride (MPH; e.g. Ritalin) is a dopaminergic drug that is highly prescribed to adolescent males for the treatment of Attention-deficit/hyperactivity disorder. It has been suggested that MPH could cause transgenerational effects because MPH can affect the male germline in rodents and because paternal effects have been observed in individuals taking similar drugs (e.g. cocaine). Despite these concerns, the transgenerational effects of paternal MPH exposure are unknown. Therefore, we exposed male and female Trinidadian guppies (Poecilia reticulata) to a low, chronic dose of MPH and observed that MPH affected the anxiety/exploratory behaviour of males, but not females. Because of this male-specific effect, we investigated the transgenerational effects of MPH through the paternal line. We observed behavioural effects of paternal MPH exposure on offspring and great-grandoffspring that were not directly administered the drug, making this the first study to demonstrate that paternal MPH exposure can affect descendants. These effects were not due to differential mortality or fecundity between control and MPH lines. These results highlight the transgenerational potential of MPH.
format	article
author	Alex R. De Serrano Kimberly A. Hughes F. Helen Rodd
author_facet	Alex R. De Serrano Kimberly A. Hughes F. Helen Rodd
author_sort	Alex R. De Serrano
title	Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies
title_short	Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies
title_full	Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies
title_fullStr	Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies
title_full_unstemmed	Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies
title_sort	paternal exposure to a common pharmaceutical (ritalin) has transgenerational effects on the behaviour of trinidadian guppies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6f94a0757b3746d184cf2761657e2482
work_keys_str_mv	AT alexrdeserrano paternalexposuretoacommonpharmaceuticalritalinhastransgenerationaleffectsonthebehaviouroftrinidadianguppies AT kimberlyahughes paternalexposuretoacommonpharmaceuticalritalinhastransgenerationaleffectsonthebehaviouroftrinidadianguppies AT fhelenrodd paternalexposuretoacommonpharmaceuticalritalinhastransgenerationaleffectsonthebehaviouroftrinidadianguppies
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Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies

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