Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controlling the integrity of tissue.

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Autores principales:	Christine-Maria Horejs, Jean-Philippe St-Pierre, Juha R. M. Ojala, Joseph A. M. Steele, Patricia Barros da Silva, Angela Rynne-Vidal, Stephanie A. Maynard, Catherine S. Hansel, Clara Rodríguez-Fernández, Manuel M. Mazo, Amanda Y. F. You, Alex J. Wang, Thomas von Erlach, Karl Tryggvason, Manuel López-Cabrera, Molly M. Stevens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6f96d69568c34d5fb8957a8cd8f04a9a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:6f96d69568c34d5fb8957a8cd8f04a9a2021-12-02T15:39:00ZPreventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information10.1038/ncomms155092041-1723https://doaj.org/article/6f96d69568c34d5fb8957a8cd8f04a9a2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15509https://doaj.org/toc/2041-1723Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controlling the integrity of tissue.Christine-Maria HorejsJean-Philippe St-PierreJuha R. M. OjalaJoseph A. M. SteelePatricia Barros da SilvaAngela Rynne-VidalStephanie A. MaynardCatherine S. HanselClara Rodríguez-FernándezManuel M. MazoAmanda Y. F. YouAlex J. WangThomas von ErlachKarl TryggvasonManuel López-CabreraMolly M. StevensNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine-Maria Horejs Jean-Philippe St-Pierre Juha R. M. Ojala Joseph A. M. Steele Patricia Barros da Silva Angela Rynne-Vidal Stephanie A. Maynard Catherine S. Hansel Clara Rodríguez-Fernández Manuel M. Mazo Amanda Y. F. You Alex J. Wang Thomas von Erlach Karl Tryggvason Manuel López-Cabrera Molly M. Stevens Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
description	Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controlling the integrity of tissue.
format	article
author	Christine-Maria Horejs Jean-Philippe St-Pierre Juha R. M. Ojala Joseph A. M. Steele Patricia Barros da Silva Angela Rynne-Vidal Stephanie A. Maynard Catherine S. Hansel Clara Rodríguez-Fernández Manuel M. Mazo Amanda Y. F. You Alex J. Wang Thomas von Erlach Karl Tryggvason Manuel López-Cabrera Molly M. Stevens
author_facet	Christine-Maria Horejs Jean-Philippe St-Pierre Juha R. M. Ojala Joseph A. M. Steele Patricia Barros da Silva Angela Rynne-Vidal Stephanie A. Maynard Catherine S. Hansel Clara Rodríguez-Fernández Manuel M. Mazo Amanda Y. F. You Alex J. Wang Thomas von Erlach Karl Tryggvason Manuel López-Cabrera Molly M. Stevens
author_sort	Christine-Maria Horejs
title	Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
title_short	Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
title_full	Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
title_fullStr	Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
title_full_unstemmed	Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
title_sort	preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6f96d69568c34d5fb8957a8cd8f04a9a
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Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

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