Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis

Curcumin has been demonstrated to be an anti-tumor agent in many types of cancers, including gastric cancer (GC). However, the molecular mechanisms by which curcumin performs its anti-tumor effects remain elusive. circ_0056618 and miR-194-5p are reported to be involved in GC progression, but their r...

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Autores principales:	Li Shan, Zhang Lihai, Li Shuhua, Zhao Hengyi, Chen Yonggang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	gastric cancer curcumin circ_0056618 mir-194-5p Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6f9785251b0e440b9c0b763fa3ba197a
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spelling	oai:doaj.org-article:6f9785251b0e440b9c0b763fa3ba197a2021-12-05T14:10:41ZCurcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis2391-541210.1515/biol-2021-0092https://doaj.org/article/6f9785251b0e440b9c0b763fa3ba197a2021-09-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0092https://doaj.org/toc/2391-5412Curcumin has been demonstrated to be an anti-tumor agent in many types of cancers, including gastric cancer (GC). However, the molecular mechanisms by which curcumin performs its anti-tumor effects remain elusive. circ_0056618 and miR-194-5p are reported to be involved in GC progression, but their relationships with curcumin are unclear. In this study, circ_0056618 was elevated, and miR-194-5p was reduced in GC tissues and cells. Curcumin treatment led to a decrease in circ_0056618 level in GC cells. Overexpression of circ_0056618 promoted cell proliferation, migration, and invasion and suppressed cell cycle arrest and apoptosis in curcumin-treated GC cells. Moreover, miR-194-5p was identified as the target of circ_0056618, and its expression in GC cells increased after curcumin treatment. Overexpression of miR-194-5p reversed the promotional effect of circ_0056618 on cell progression in curcumin-treated GC cells. Additionally, curcumin treatment repressed the tumorigenesis of GC in vivo through regulating circ_0056618. Curcumin treatment delayed the development of GC partly through decreasing circ_0056618 and increasing miR-194-5p.Li ShanZhang LihaiLi ShuhuaZhao HengyiChen YonggangDe Gruyterarticlegastric cancercurcumincirc_0056618mir-194-5pBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 937-949 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer curcumin circ_0056618 mir-194-5p Biology (General) QH301-705.5
spellingShingle	gastric cancer curcumin circ_0056618 mir-194-5p Biology (General) QH301-705.5 Li Shan Zhang Lihai Li Shuhua Zhao Hengyi Chen Yonggang Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
description	Curcumin has been demonstrated to be an anti-tumor agent in many types of cancers, including gastric cancer (GC). However, the molecular mechanisms by which curcumin performs its anti-tumor effects remain elusive. circ_0056618 and miR-194-5p are reported to be involved in GC progression, but their relationships with curcumin are unclear. In this study, circ_0056618 was elevated, and miR-194-5p was reduced in GC tissues and cells. Curcumin treatment led to a decrease in circ_0056618 level in GC cells. Overexpression of circ_0056618 promoted cell proliferation, migration, and invasion and suppressed cell cycle arrest and apoptosis in curcumin-treated GC cells. Moreover, miR-194-5p was identified as the target of circ_0056618, and its expression in GC cells increased after curcumin treatment. Overexpression of miR-194-5p reversed the promotional effect of circ_0056618 on cell progression in curcumin-treated GC cells. Additionally, curcumin treatment repressed the tumorigenesis of GC in vivo through regulating circ_0056618. Curcumin treatment delayed the development of GC partly through decreasing circ_0056618 and increasing miR-194-5p.
format	article
author	Li Shan Zhang Lihai Li Shuhua Zhao Hengyi Chen Yonggang
author_facet	Li Shan Zhang Lihai Li Shuhua Zhao Hengyi Chen Yonggang
author_sort	Li Shan
title	Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
title_short	Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
title_full	Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
title_fullStr	Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
title_full_unstemmed	Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis
title_sort	curcumin suppresses the progression of gastric cancer by regulating circ_0056618/mir-194-5p axis
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/6f9785251b0e440b9c0b763fa3ba197a
work_keys_str_mv	AT lishan curcuminsuppressestheprogressionofgastriccancerbyregulatingcirc0056618mir1945paxis AT zhanglihai curcuminsuppressestheprogressionofgastriccancerbyregulatingcirc0056618mir1945paxis AT lishuhua curcuminsuppressestheprogressionofgastriccancerbyregulatingcirc0056618mir1945paxis AT zhaohengyi curcuminsuppressestheprogressionofgastriccancerbyregulatingcirc0056618mir1945paxis AT chenyonggang curcuminsuppressestheprogressionofgastriccancerbyregulatingcirc0056618mir1945paxis
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Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis

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