Cancer stem cell theory: therapeutic implications for nanomedicine

Ke Wang,1 Xianguo Wu,2 Jianwei Wang,3 Jian Huang1,31Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), 2Department of Clinical Laboratory, 3Department of Oncology, Second Affilia...

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Autores principales:	Wang K, Wu X, Wang J, Huang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6f983a4389a946d98087d215297148cb
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spelling	oai:doaj.org-article:6f983a4389a946d98087d215297148cb2021-12-02T02:10:28ZCancer stem cell theory: therapeutic implications for nanomedicine1176-91141178-2013https://doaj.org/article/6f983a4389a946d98087d215297148cb2013-02-01T00:00:00Zhttp://www.dovepress.com/cancer-stem-cell-theory-therapeutic-implications-for-nanomedicine-a12324https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ke Wang,1 Xianguo Wu,2 Jianwei Wang,3 Jian Huang1,31Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), 2Department of Clinical Laboratory, 3Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People&#39;s Republic of ChinaAbstract: Evidence continues to accumulate showing that tumors contain a minority population of cells responsible for tumor initiation, growth, and recurrence. These are termed &quot;cancer stem cells&quot; (CSCs). Functional assays have identified the self-renewal and tumor-initiation capabilities of CSCs. Moreover, recent studies have revealed that these CSCs is responsible for chemotherapy resistance within a tumor. Several mechanisms of chemoresistance have been proposed, including increased Wnt/&beta;-catenin and Notch signaling, as well as high expression levels of adenosine triphosphate-binding cassette transporters, an active DNA repair capacity, and slow rate of self-renewal. Nanoscale drug-delivery systems, which transport therapeutically active molecules, prolong circulation, and improve biodistribution in the body, may allow more effective and specific therapies to address the challenges posed by CSCs. In particular, some nanovehicles are being exploited for selective drug delivery to CSCs and show promising results. In this review, we highlight the mechanisms of drug resistance and the novel strategies using nanoscale drugs to eliminate CSCs.Keywords: drug resistance, drug delivery, chemoresistance, Wnt/&beta;-catenin signaling, Notch signalingWang KWu XWang JHuang JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 899-908 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang K Wu X Wang J Huang J Cancer stem cell theory: therapeutic implications for nanomedicine
description	Ke Wang,1 Xianguo Wu,2 Jianwei Wang,3 Jian Huang1,31Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education; Provincial Key Laboratory of Molecular Biology in Medical Sciences), 2Department of Clinical Laboratory, 3Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People&#39;s Republic of ChinaAbstract: Evidence continues to accumulate showing that tumors contain a minority population of cells responsible for tumor initiation, growth, and recurrence. These are termed &quot;cancer stem cells&quot; (CSCs). Functional assays have identified the self-renewal and tumor-initiation capabilities of CSCs. Moreover, recent studies have revealed that these CSCs is responsible for chemotherapy resistance within a tumor. Several mechanisms of chemoresistance have been proposed, including increased Wnt/&beta;-catenin and Notch signaling, as well as high expression levels of adenosine triphosphate-binding cassette transporters, an active DNA repair capacity, and slow rate of self-renewal. Nanoscale drug-delivery systems, which transport therapeutically active molecules, prolong circulation, and improve biodistribution in the body, may allow more effective and specific therapies to address the challenges posed by CSCs. In particular, some nanovehicles are being exploited for selective drug delivery to CSCs and show promising results. In this review, we highlight the mechanisms of drug resistance and the novel strategies using nanoscale drugs to eliminate CSCs.Keywords: drug resistance, drug delivery, chemoresistance, Wnt/&beta;-catenin signaling, Notch signaling
format	article
author	Wang K Wu X Wang J Huang J
author_facet	Wang K Wu X Wang J Huang J
author_sort	Wang K
title	Cancer stem cell theory: therapeutic implications for nanomedicine
title_short	Cancer stem cell theory: therapeutic implications for nanomedicine
title_full	Cancer stem cell theory: therapeutic implications for nanomedicine
title_fullStr	Cancer stem cell theory: therapeutic implications for nanomedicine
title_full_unstemmed	Cancer stem cell theory: therapeutic implications for nanomedicine
title_sort	cancer stem cell theory: therapeutic implications for nanomedicine
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6f983a4389a946d98087d215297148cb
work_keys_str_mv	AT wangk cancerstemcelltheorytherapeuticimplicationsfornanomedicine AT wux cancerstemcelltheorytherapeuticimplicationsfornanomedicine AT wangj cancerstemcelltheorytherapeuticimplicationsfornanomedicine AT huangj cancerstemcelltheorytherapeuticimplicationsfornanomedicine
_version_	1718402654206427136

Cancer stem cell theory: therapeutic implications for nanomedicine

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