Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies

Many fluid biomarker findings have had low reproducibility despite initially promising results. Here, the authors review possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases and suggest guidelines for the biomarker community to agree on and implement...

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Autores principales: Niklas Mattsson-Carlgren, Sebastian Palmqvist, Kaj Blennow, Oskar Hansson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6f9ad7fe719b463fa1f77344a46120a2
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Sumario:Many fluid biomarker findings have had low reproducibility despite initially promising results. Here, the authors review possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases and suggest guidelines for the biomarker community to agree on and implement.