Impaired trunk stability in individuals at high risk for Parkinson's disease.

<h4>Background</h4>The search for disease-modifying treatments for Parkinson's disease advances, however necessary markers for early detection of the disease are still lacking. There is compelling evidence that changes of postural stability occur at very early clinical stages of Par...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Walter Maetzler, Martina Mancini, Inga Liepelt-Scarfone, Katharina Müller, Clemens Becker, Rob C van Lummel, Erik Ainsworth, Markus Hobert, Johannes Streffer, Daniela Berg, Lorenzo Chiari
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fa0f16d18af40ada231d8166f3a4f79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6fa0f16d18af40ada231d8166f3a4f79
record_format	dspace
spelling	oai:doaj.org-article:6fa0f16d18af40ada231d8166f3a4f792021-11-18T07:24:27ZImpaired trunk stability in individuals at high risk for Parkinson's disease.1932-620310.1371/journal.pone.0032240https://doaj.org/article/6fa0f16d18af40ada231d8166f3a4f792012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22457713/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The search for disease-modifying treatments for Parkinson's disease advances, however necessary markers for early detection of the disease are still lacking. There is compelling evidence that changes of postural stability occur at very early clinical stages of Parkinson's disease, making it tempting to speculate that changes in sway performance may even occur at a prodromal stage, and may have the potential to serve as a prodromal marker for the disease.<h4>Methodology/principal findings</h4>Balance performance was tested in 20 individuals with an increased risk of Parkinson's disease, 12 Parkinson's disease patients and 14 controls using a cross-sectional approach. All individuals were 50 years or older. Investigated groups were similar with respect to age, gender, and height. An accelerometer at the centre of mass at the lower spine quantified sway during quiet semitandem stance with eyes open and closed, as well as with and without foam. With increasing task difficulty, individuals with an increased risk of Parkinson's disease showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to both other groups. These differences reached significance in the most challenging condition, i.e. the eyes closed with foam condition.<h4>Conclusions/significance</h4>Individuals with an increased risk of Parkinson's disease have subtle signs of a balance deficit under most challenging conditions. This preliminary finding should motivate further studies on sway performance in individuals with an increased risk of Parkinson's disease, to evaluate the potential of this symptom to serve as a biological marker for prodromal Parkinson's disease.Walter MaetzlerMartina ManciniInga Liepelt-ScarfoneKatharina MüllerClemens BeckerRob C van LummelErik AinsworthMarkus HobertJohannes StrefferDaniela BergLorenzo ChiariPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e32240 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Walter Maetzler Martina Mancini Inga Liepelt-Scarfone Katharina Müller Clemens Becker Rob C van Lummel Erik Ainsworth Markus Hobert Johannes Streffer Daniela Berg Lorenzo Chiari Impaired trunk stability in individuals at high risk for Parkinson's disease.
description	<h4>Background</h4>The search for disease-modifying treatments for Parkinson's disease advances, however necessary markers for early detection of the disease are still lacking. There is compelling evidence that changes of postural stability occur at very early clinical stages of Parkinson's disease, making it tempting to speculate that changes in sway performance may even occur at a prodromal stage, and may have the potential to serve as a prodromal marker for the disease.<h4>Methodology/principal findings</h4>Balance performance was tested in 20 individuals with an increased risk of Parkinson's disease, 12 Parkinson's disease patients and 14 controls using a cross-sectional approach. All individuals were 50 years or older. Investigated groups were similar with respect to age, gender, and height. An accelerometer at the centre of mass at the lower spine quantified sway during quiet semitandem stance with eyes open and closed, as well as with and without foam. With increasing task difficulty, individuals with an increased risk of Parkinson's disease showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to both other groups. These differences reached significance in the most challenging condition, i.e. the eyes closed with foam condition.<h4>Conclusions/significance</h4>Individuals with an increased risk of Parkinson's disease have subtle signs of a balance deficit under most challenging conditions. This preliminary finding should motivate further studies on sway performance in individuals with an increased risk of Parkinson's disease, to evaluate the potential of this symptom to serve as a biological marker for prodromal Parkinson's disease.
format	article
author	Walter Maetzler Martina Mancini Inga Liepelt-Scarfone Katharina Müller Clemens Becker Rob C van Lummel Erik Ainsworth Markus Hobert Johannes Streffer Daniela Berg Lorenzo Chiari
author_facet	Walter Maetzler Martina Mancini Inga Liepelt-Scarfone Katharina Müller Clemens Becker Rob C van Lummel Erik Ainsworth Markus Hobert Johannes Streffer Daniela Berg Lorenzo Chiari
author_sort	Walter Maetzler
title	Impaired trunk stability in individuals at high risk for Parkinson's disease.
title_short	Impaired trunk stability in individuals at high risk for Parkinson's disease.
title_full	Impaired trunk stability in individuals at high risk for Parkinson's disease.
title_fullStr	Impaired trunk stability in individuals at high risk for Parkinson's disease.
title_full_unstemmed	Impaired trunk stability in individuals at high risk for Parkinson's disease.
title_sort	impaired trunk stability in individuals at high risk for parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6fa0f16d18af40ada231d8166f3a4f79
work_keys_str_mv	AT waltermaetzler impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT martinamancini impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT ingaliepeltscarfone impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT katharinamuller impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT clemensbecker impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT robcvanlummel impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT erikainsworth impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT markushobert impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT johannesstreffer impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT danielaberg impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease AT lorenzochiari impairedtrunkstabilityinindividualsathighriskforparkinsonsdisease
_version_	1718423480422105088

Impaired trunk stability in individuals at high risk for Parkinson's disease.

Ejemplares similares