Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens.

Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens.

The branched M33 antimicrobial peptide was previously shown to be very active against Gram-negative bacterial pathogens, including multidrug-resistant strains. In an attempt to produce back-up molecules, we synthesized an M33 peptide isomer consisting of D-aminoacids (M33-D). This isomeric version s...

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Autores principales: Chiara Falciani, Luisa Lozzi, Simona Pollini, Vincenzo Luca, Veronica Carnicelli, Jlenia Brunetti, Barbara Lelli, Stefano Bindi, Silvia Scali, Antonio Di Giulio, Gian Maria Rossolini, Maria Luisa Mangoni, Luisa Bracci, Alessandro Pini
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6fa108c5020d4f499fc5bcf653798a8e
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