Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection

Ya-Lang Huang et al. report a mechanism for TLR3-mediated signaling after immune simulation and influenza virus infection by way of the co-receptor CLEC18A. This study found that a single amino acid change in CLEC18A(S339R) can enhance the production of type I and type III interferons to suppress vi...

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Autores principales:	Ya-Lang Huang, Ming-Ting Huang, Pei-Shan Sung, Teh-Ying Chou, Ruey-Bing Yang, An-Suei Yang, Chung-Ming Yu, Yu-Wen Hsu, Wei-Chiao Chang, Shie-Liang Hsieh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6fa2f4a4e45c413fa7b217a06e675fd7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:6fa2f4a4e45c413fa7b217a06e675fd72021-12-02T12:11:51ZEndosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection10.1038/s42003-021-01745-72399-3642https://doaj.org/article/6fa2f4a4e45c413fa7b217a06e675fd72021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01745-7https://doaj.org/toc/2399-3642Ya-Lang Huang et al. report a mechanism for TLR3-mediated signaling after immune simulation and influenza virus infection by way of the co-receptor CLEC18A. This study found that a single amino acid change in CLEC18A(S339R) can enhance the production of type I and type III interferons to suppress viral replication, and increase mice survival rate after flu infection infection.Ya-Lang HuangMing-Ting HuangPei-Shan SungTeh-Ying ChouRuey-Bing YangAn-Suei YangChung-Ming YuYu-Wen HsuWei-Chiao ChangShie-Liang HsiehNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ya-Lang Huang Ming-Ting Huang Pei-Shan Sung Teh-Ying Chou Ruey-Bing Yang An-Suei Yang Chung-Ming Yu Yu-Wen Hsu Wei-Chiao Chang Shie-Liang Hsieh Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
description	Ya-Lang Huang et al. report a mechanism for TLR3-mediated signaling after immune simulation and influenza virus infection by way of the co-receptor CLEC18A. This study found that a single amino acid change in CLEC18A(S339R) can enhance the production of type I and type III interferons to suppress viral replication, and increase mice survival rate after flu infection infection.
format	article
author	Ya-Lang Huang Ming-Ting Huang Pei-Shan Sung Teh-Ying Chou Ruey-Bing Yang An-Suei Yang Chung-Ming Yu Yu-Wen Hsu Wei-Chiao Chang Shie-Liang Hsieh
author_facet	Ya-Lang Huang Ming-Ting Huang Pei-Shan Sung Teh-Ying Chou Ruey-Bing Yang An-Suei Yang Chung-Ming Yu Yu-Wen Hsu Wei-Chiao Chang Shie-Liang Hsieh
author_sort	Ya-Lang Huang
title	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
title_short	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
title_full	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
title_fullStr	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
title_full_unstemmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
title_sort	endosomal tlr3 co-receptor clec18a enhances host immune response to viral infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6fa2f4a4e45c413fa7b217a06e675fd7
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Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection

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