Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.

<h4>Background</h4>Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and th...

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Autores principales:	Barry R Palmer, Melinda A Paterson, Chris M Frampton, Anna P Pilbrow, Lorraine Skelton, Chris J Pemberton, Robert N Doughty, Chris J Ellis, Richard W Troughton, A Mark Richards, Vicky A Cameron
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fa3494f411c4b08af18bcb3f58ba37b
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spelling	oai:doaj.org-article:6fa3494f411c4b08af18bcb3f58ba37b2021-12-02T20:07:03ZVascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.1932-620310.1371/journal.pone.0254206https://doaj.org/article/6fa3494f411c4b08af18bcb3f58ba37b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254206https://doaj.org/toc/1932-6203<h4>Background</h4>Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variants in the VEGFA gene in a clinical coronary cohort.<h4>Methods and results</h4>The Coronary Disease Cohort Study (CDCS) recruited 2,140 patients, with a diagnosis of acute coronary syndrome (ACS), after admission to Christchurch or Auckland City Hospitals between July 2002 and January 2009. We present data for 1927 patients from the cohort genotyped for three SNPs in the VEGF-A gene, rs699947 (C-2578A), rs2010963 (C405G) and rs3025039 (C936T). Plasma VEGF-A concentrations were assayed in a subgroup (n = 550) of CDCS patients (geometric mean 36.6 [34.7-38.5] pg/ml). VEGF-A levels correlated with patient heart rate at baseline (p = 0.034). None of rs699947, rs3025039, nor rs2010963 genotypes were significantly associated with VEGF-A levels, but rs3025039 genotype was positively associated with collateral vessels perfusion according to the Rentrop classification (p = 0.01) and baseline natriuretic peptide levels (p<0.05). Survival in the CDCS cohort was independently associated with baseline VEGF-A levels and (in males) with rs699947 genotype.<h4>Conclusions</h4>This study is strongly suggestive that VEGF-A levels have value as a prognostic biomarker in coronary heart disease patients and SNPs in VEGF-A deserve further investigation as prognostic markers and indicators of angiogenic potential influencing the formation of collateral circulation.Barry R PalmerMelinda A PatersonChris M FramptonAnna P PilbrowLorraine SkeltonChris J PembertonRobert N DoughtyChris J EllisRichard W TroughtonA Mark RichardsVicky A CameronPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254206 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barry R Palmer Melinda A Paterson Chris M Frampton Anna P Pilbrow Lorraine Skelton Chris J Pemberton Robert N Doughty Chris J Ellis Richard W Troughton A Mark Richards Vicky A Cameron Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.
description	<h4>Background</h4>Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variants in the VEGFA gene in a clinical coronary cohort.<h4>Methods and results</h4>The Coronary Disease Cohort Study (CDCS) recruited 2,140 patients, with a diagnosis of acute coronary syndrome (ACS), after admission to Christchurch or Auckland City Hospitals between July 2002 and January 2009. We present data for 1927 patients from the cohort genotyped for three SNPs in the VEGF-A gene, rs699947 (C-2578A), rs2010963 (C405G) and rs3025039 (C936T). Plasma VEGF-A concentrations were assayed in a subgroup (n = 550) of CDCS patients (geometric mean 36.6 [34.7-38.5] pg/ml). VEGF-A levels correlated with patient heart rate at baseline (p = 0.034). None of rs699947, rs3025039, nor rs2010963 genotypes were significantly associated with VEGF-A levels, but rs3025039 genotype was positively associated with collateral vessels perfusion according to the Rentrop classification (p = 0.01) and baseline natriuretic peptide levels (p<0.05). Survival in the CDCS cohort was independently associated with baseline VEGF-A levels and (in males) with rs699947 genotype.<h4>Conclusions</h4>This study is strongly suggestive that VEGF-A levels have value as a prognostic biomarker in coronary heart disease patients and SNPs in VEGF-A deserve further investigation as prognostic markers and indicators of angiogenic potential influencing the formation of collateral circulation.
format	article
author	Barry R Palmer Melinda A Paterson Chris M Frampton Anna P Pilbrow Lorraine Skelton Chris J Pemberton Robert N Doughty Chris J Ellis Richard W Troughton A Mark Richards Vicky A Cameron
author_facet	Barry R Palmer Melinda A Paterson Chris M Frampton Anna P Pilbrow Lorraine Skelton Chris J Pemberton Robert N Doughty Chris J Ellis Richard W Troughton A Mark Richards Vicky A Cameron
author_sort	Barry R Palmer
title	Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.
title_short	Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.
title_full	Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.
title_fullStr	Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.
title_full_unstemmed	Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.
title_sort	vascular endothelial growth factor-a promoter polymorphisms, circulating vegf-a and survival in acute coronary syndromes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6fa3494f411c4b08af18bcb3f58ba37b
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Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes.

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