A method for the generation of human stem cell-derived alpha cells

Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and be...

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Autores principales:	Quinn P. Peterson, Adrian Veres, Lihua Chen, Michael Q. Slama, Jennifer H. R. Kenty, Shaimaa Hassoun, Matthew R. Brown, Haiqiang Dou, Caden D. Duffy, Quan Zhou, Aleksey V. Matveyenko, Björn Tyrberg, Maria Sörhede-Winzell, Patrik Rorsman, Douglas A. Melton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
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spelling	oai:doaj.org-article:6faab0e582834b4a8aca6528596abca22021-12-02T14:41:26ZA method for the generation of human stem cell-derived alpha cells10.1038/s41467-020-16049-32041-1723https://doaj.org/article/6faab0e582834b4a8aca6528596abca22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16049-3https://doaj.org/toc/2041-1723Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and behave as such when transplanted into mice.Quinn P. PetersonAdrian VeresLihua ChenMichael Q. SlamaJennifer H. R. KentyShaimaa HassounMatthew R. BrownHaiqiang DouCaden D. DuffyQuan ZhouAleksey V. MatveyenkoBjörn TyrbergMaria Sörhede-WinzellPatrik RorsmanDouglas A. MeltonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quinn P. Peterson Adrian Veres Lihua Chen Michael Q. Slama Jennifer H. R. Kenty Shaimaa Hassoun Matthew R. Brown Haiqiang Dou Caden D. Duffy Quan Zhou Aleksey V. Matveyenko Björn Tyrberg Maria Sörhede-Winzell Patrik Rorsman Douglas A. Melton A method for the generation of human stem cell-derived alpha cells
description	Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and behave as such when transplanted into mice.
format	article
author	Quinn P. Peterson Adrian Veres Lihua Chen Michael Q. Slama Jennifer H. R. Kenty Shaimaa Hassoun Matthew R. Brown Haiqiang Dou Caden D. Duffy Quan Zhou Aleksey V. Matveyenko Björn Tyrberg Maria Sörhede-Winzell Patrik Rorsman Douglas A. Melton
author_facet	Quinn P. Peterson Adrian Veres Lihua Chen Michael Q. Slama Jennifer H. R. Kenty Shaimaa Hassoun Matthew R. Brown Haiqiang Dou Caden D. Duffy Quan Zhou Aleksey V. Matveyenko Björn Tyrberg Maria Sörhede-Winzell Patrik Rorsman Douglas A. Melton
author_sort	Quinn P. Peterson
title	A method for the generation of human stem cell-derived alpha cells
title_short	A method for the generation of human stem cell-derived alpha cells
title_full	A method for the generation of human stem cell-derived alpha cells
title_fullStr	A method for the generation of human stem cell-derived alpha cells
title_full_unstemmed	A method for the generation of human stem cell-derived alpha cells
title_sort	method for the generation of human stem cell-derived alpha cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6faab0e582834b4a8aca6528596abca2
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A method for the generation of human stem cell-derived alpha cells

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