Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months

Post-stroke depression (PSD) affects approximately one-third of stroke patients. PSD not only impairs recovery and lowers quality of life, but has also serious neurological consequences, high mortality, and stroke recurrence risks. Studies on PSD-related prognostic factors are still lacking, especia...

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Autores principales: Chan-Hyuk Lee, Su Hong Jeon, Min Ju Kim, Gyu Dam Ra, Yong-Hyun Lee, Seung Hyeon Hong, Byoung-Soo Shin, Hyun Goo Kang
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spelling oai:doaj.org-article:6faef8d1f343426b8f814b89eb8644c92021-11-25T18:07:49ZFactors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months10.3390/jpm111111782075-4426https://doaj.org/article/6faef8d1f343426b8f814b89eb8644c92021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1178https://doaj.org/toc/2075-4426Post-stroke depression (PSD) affects approximately one-third of stroke patients. PSD not only impairs recovery and lowers quality of life, but has also serious neurological consequences, high mortality, and stroke recurrence risks. Studies on PSD-related prognostic factors are still lacking, especially environmental factors. Moreover, relieving factors after PSD in stroke patients has not been reported. This study aimed to investigate (study design 1) risk factors for PSD diagnosis after three months, and (study design 2) related factors for the relieving of early PSD after three months. This retrospective study included 227 patients hospitalized for acute ischemic stroke within three days at Jeonbuk National University Hospital from January to December 2019. The depressive status was assessed using the Hamilton Depression Rating Scale (HDRS) at admission and after three months. Clinical and laboratory data were analyzed for relevant prognostic factors. (Study design 1) HDRS score at admission (adjusted odds ratio (aOR) 1.22, 95% confidence interval (CI) 1.14–1.31; <i>p</i> < 0.001) and hospitalization period (aOR 1.11, 95% CI 1.02–1.20; <i>p</i> = 0.013) were confirmed as prognostic factors of PSD after three months. (Study design 2) The National Institute of Health Stroke Scale (NIHSS) score at discharge (aOR 0.80, 95% CI 0.68–0.94; <i>p</i> = 0.006) and HDRS score at admission (aOR 0.80, 95% CI 0.71–0.89; <i>p</i> < 0.001) were confirmed as prognostic factors of depression improvement after three months. In conclusion, environmental factors such as hospitalization period could be important in managing PSD. Factors related to PSD improvement are expected to be helpful in establishing a strategy for PSD recovery.Chan-Hyuk LeeSu Hong JeonMin Ju KimGyu Dam RaYong-Hyun LeeSeung Hyeon HongByoung-Soo ShinHyun Goo KangMDPI AGarticleHamilton Depression Rating Scaleischemic strokepost-stroke depressionprognosisMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1178, p 1178 (2021)
institution DOAJ
collection DOAJ
language EN
topic Hamilton Depression Rating Scale
ischemic stroke
post-stroke depression
prognosis
Medicine
R
spellingShingle Hamilton Depression Rating Scale
ischemic stroke
post-stroke depression
prognosis
Medicine
R
Chan-Hyuk Lee
Su Hong Jeon
Min Ju Kim
Gyu Dam Ra
Yong-Hyun Lee
Seung Hyeon Hong
Byoung-Soo Shin
Hyun Goo Kang
Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
description Post-stroke depression (PSD) affects approximately one-third of stroke patients. PSD not only impairs recovery and lowers quality of life, but has also serious neurological consequences, high mortality, and stroke recurrence risks. Studies on PSD-related prognostic factors are still lacking, especially environmental factors. Moreover, relieving factors after PSD in stroke patients has not been reported. This study aimed to investigate (study design 1) risk factors for PSD diagnosis after three months, and (study design 2) related factors for the relieving of early PSD after three months. This retrospective study included 227 patients hospitalized for acute ischemic stroke within three days at Jeonbuk National University Hospital from January to December 2019. The depressive status was assessed using the Hamilton Depression Rating Scale (HDRS) at admission and after three months. Clinical and laboratory data were analyzed for relevant prognostic factors. (Study design 1) HDRS score at admission (adjusted odds ratio (aOR) 1.22, 95% confidence interval (CI) 1.14–1.31; <i>p</i> < 0.001) and hospitalization period (aOR 1.11, 95% CI 1.02–1.20; <i>p</i> = 0.013) were confirmed as prognostic factors of PSD after three months. (Study design 2) The National Institute of Health Stroke Scale (NIHSS) score at discharge (aOR 0.80, 95% CI 0.68–0.94; <i>p</i> = 0.006) and HDRS score at admission (aOR 0.80, 95% CI 0.71–0.89; <i>p</i> < 0.001) were confirmed as prognostic factors of depression improvement after three months. In conclusion, environmental factors such as hospitalization period could be important in managing PSD. Factors related to PSD improvement are expected to be helpful in establishing a strategy for PSD recovery.
format article
author Chan-Hyuk Lee
Su Hong Jeon
Min Ju Kim
Gyu Dam Ra
Yong-Hyun Lee
Seung Hyeon Hong
Byoung-Soo Shin
Hyun Goo Kang
author_facet Chan-Hyuk Lee
Su Hong Jeon
Min Ju Kim
Gyu Dam Ra
Yong-Hyun Lee
Seung Hyeon Hong
Byoung-Soo Shin
Hyun Goo Kang
author_sort Chan-Hyuk Lee
title Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_short Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_full Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_fullStr Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_full_unstemmed Factors Affecting Post-Stroke Depression in Acute Ischemic Stroke Patients after 3 Months
title_sort factors affecting post-stroke depression in acute ischemic stroke patients after 3 months
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/6faef8d1f343426b8f814b89eb8644c9
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