Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study

Ibrahim Y Allam,1 Sihem Lazreg,2 Mohamed Shafik Shaheen,1 Mohamed Fahmy Doheim,1 Mai A Mohammed1 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Cabinet Ophtalmologie, Alger Centre, Algiers, AlgeriaCorrespondence: Ibrahim Y AllamOphthalmology Department, Fa...

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Autores principales:	Allam IY, Lazreg S, Shafik Shaheen M, Doheim MF, Mohammed MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	thyroid eye disease dry eye disease ocular surface thyroid antibodies Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6faf677d9f13430e9ba723e85116e405
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spelling	oai:doaj.org-article:6faf677d9f13430e9ba723e85116e4052021-12-02T16:02:31ZOcular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study1177-5483https://doaj.org/article/6faf677d9f13430e9ba723e85116e4052021-06-01T00:00:00Zhttps://www.dovepress.com/ocular-surface-changes-in-patients-with-thyroid-eye-disease-an-observa-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Ibrahim Y Allam,1 Sihem Lazreg,2 Mohamed Shafik Shaheen,1 Mohamed Fahmy Doheim,1 Mai A Mohammed1 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Cabinet Ophtalmologie, Alger Centre, Algiers, AlgeriaCorrespondence: Ibrahim Y AllamOphthalmology Department, Faculty of Medicine, Alexandria University, El Maram Building, 3 rd Mostafa Kamel St., Smouha, Alexandria, 21615, EgyptTel +201001233126Fax +2034210443Email ibrahimallam2007@gmail.comBackground: This study aimed to compare ocular surface parameter changes in active and inactive thyroid eye disease (TED) patients and controls.Methods: This is an observational clinical study that included 60 eyes divided into three groups following clinical activity score (CAS) assessment. The first group (Group A) comprised 20 eyes with active TED (CAS score ≥ 3/7), while the second group (Group B) comprised 20 eyes with inactive TED (CAS score < 3/7) and the third group (Group C) comprised 20 eyes of controls without dry eye manifestations. The palpebral fissure height, degree of proptosis, degree of lagophthalmos, ocular surface disease index (OSDI), Schirmer test without anesthesia, corneal fluorescein staining (CFS), non-invasive tear break-up time (NITBUT), tear meniscus height (TMH), lipid layer thickness (LLT), meiboscore, meibomian gland dysfunction (MGD), and thyroid antibodies were assessed and data were compared between study participants.Results: The mean OSDI was 40.0 ± 5.80 in Group A, which significantly differed from Group B with a mean of 26.5 ± 5.10 (p=0.02). There were significant differences between the two groups regarding palpebral fissure height (p=0.02), amount of proptosis (p=0.008), and degree of lagophthalmos (p=0.001). Similarly, active TED patients had more decreased tear secretion than inactive TED patients (p=0.012). Moreover, active TED patients showed a significant increase in Meibomian gland loss areas in both upper and lower eyelids compared with inactive TED patients (p=0.001). Corneal fluorescein staining also revealed a statistically significant difference between the studied groups (p=0.0001).Conclusion: This study showed differences regarding ocular surface parameter changes between both active and inactive TED and compared to controls. Further studies are needed to confirm these results.Keywords: thyroid eye disease, dry eye disease, ocular surface, thyroid antibodiesAllam IYLazreg SShafik Shaheen MDoheim MFMohammed MADove Medical Pressarticlethyroid eye diseasedry eye diseaseocular surfacethyroid antibodiesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2481-2488 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid eye disease dry eye disease ocular surface thyroid antibodies Ophthalmology RE1-994
spellingShingle	thyroid eye disease dry eye disease ocular surface thyroid antibodies Ophthalmology RE1-994 Allam IY Lazreg S Shafik Shaheen M Doheim MF Mohammed MA Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study
description	Ibrahim Y Allam,1 Sihem Lazreg,2 Mohamed Shafik Shaheen,1 Mohamed Fahmy Doheim,1 Mai A Mohammed1 1Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt; 2Cabinet Ophtalmologie, Alger Centre, Algiers, AlgeriaCorrespondence: Ibrahim Y AllamOphthalmology Department, Faculty of Medicine, Alexandria University, El Maram Building, 3 rd Mostafa Kamel St., Smouha, Alexandria, 21615, EgyptTel +201001233126Fax +2034210443Email ibrahimallam2007@gmail.comBackground: This study aimed to compare ocular surface parameter changes in active and inactive thyroid eye disease (TED) patients and controls.Methods: This is an observational clinical study that included 60 eyes divided into three groups following clinical activity score (CAS) assessment. The first group (Group A) comprised 20 eyes with active TED (CAS score ≥ 3/7), while the second group (Group B) comprised 20 eyes with inactive TED (CAS score < 3/7) and the third group (Group C) comprised 20 eyes of controls without dry eye manifestations. The palpebral fissure height, degree of proptosis, degree of lagophthalmos, ocular surface disease index (OSDI), Schirmer test without anesthesia, corneal fluorescein staining (CFS), non-invasive tear break-up time (NITBUT), tear meniscus height (TMH), lipid layer thickness (LLT), meiboscore, meibomian gland dysfunction (MGD), and thyroid antibodies were assessed and data were compared between study participants.Results: The mean OSDI was 40.0 ± 5.80 in Group A, which significantly differed from Group B with a mean of 26.5 ± 5.10 (p=0.02). There were significant differences between the two groups regarding palpebral fissure height (p=0.02), amount of proptosis (p=0.008), and degree of lagophthalmos (p=0.001). Similarly, active TED patients had more decreased tear secretion than inactive TED patients (p=0.012). Moreover, active TED patients showed a significant increase in Meibomian gland loss areas in both upper and lower eyelids compared with inactive TED patients (p=0.001). Corneal fluorescein staining also revealed a statistically significant difference between the studied groups (p=0.0001).Conclusion: This study showed differences regarding ocular surface parameter changes between both active and inactive TED and compared to controls. Further studies are needed to confirm these results.Keywords: thyroid eye disease, dry eye disease, ocular surface, thyroid antibodies
format	article
author	Allam IY Lazreg S Shafik Shaheen M Doheim MF Mohammed MA
author_facet	Allam IY Lazreg S Shafik Shaheen M Doheim MF Mohammed MA
author_sort	Allam IY
title	Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study
title_short	Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study
title_full	Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study
title_fullStr	Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study
title_full_unstemmed	Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study
title_sort	ocular surface changes in patients with thyroid eye disease: an observational clinical study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6faf677d9f13430e9ba723e85116e405
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_version_	1718385278827102208

Ocular Surface Changes in Patients with Thyroid Eye Disease: An Observational Clinical Study

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