Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015

Abstract The spread of carbapenemase-producing Enterobacteriaceae (CPE) in healthcare settings is a major public health threat that has been associated with cross-border and local patient transfers between healthcare facilities. Since the impact of transfers on spread may vary, our study aimed to as...

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Autores principales:	Narimane Nekkab, Pascal Crépey, Pascal Astagneau, Lulla Opatowski, Laura Temime
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fb29d6d86da41c48ff6ee40f7792a27
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spelling	oai:doaj.org-article:6fb29d6d86da41c48ff6ee40f7792a272021-12-02T19:12:28ZAssessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 201510.1038/s41598-020-71212-62045-2322https://doaj.org/article/6fb29d6d86da41c48ff6ee40f7792a272020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-71212-6https://doaj.org/toc/2045-2322Abstract The spread of carbapenemase-producing Enterobacteriaceae (CPE) in healthcare settings is a major public health threat that has been associated with cross-border and local patient transfers between healthcare facilities. Since the impact of transfers on spread may vary, our study aimed to assess the contribution of a patient transfer network on CPE incidence and spread at a countrywide level, with a case study of France from 2012 to 2015. Our results suggest a transition in 2013 from a CPE epidemic sustained by internationally imported episodes to an epidemic sustained by local transmission events through patient transfers. Incident episodes tend to occur within close spatial distance of their potential infector. We also observe an increasing frequency of multiple spreading events, originating from a limited number of regional hubs. Consequently, coordinated prevention and infection control strategies should focus on transfers of carriers of CPE to reduce regional and inter-regional transmission.Narimane NekkabPascal CrépeyPascal AstagneauLulla OpatowskiLaura TemimeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Narimane Nekkab Pascal Crépey Pascal Astagneau Lulla Opatowski Laura Temime Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015
description	Abstract The spread of carbapenemase-producing Enterobacteriaceae (CPE) in healthcare settings is a major public health threat that has been associated with cross-border and local patient transfers between healthcare facilities. Since the impact of transfers on spread may vary, our study aimed to assess the contribution of a patient transfer network on CPE incidence and spread at a countrywide level, with a case study of France from 2012 to 2015. Our results suggest a transition in 2013 from a CPE epidemic sustained by internationally imported episodes to an epidemic sustained by local transmission events through patient transfers. Incident episodes tend to occur within close spatial distance of their potential infector. We also observe an increasing frequency of multiple spreading events, originating from a limited number of regional hubs. Consequently, coordinated prevention and infection control strategies should focus on transfers of carriers of CPE to reduce regional and inter-regional transmission.
format	article
author	Narimane Nekkab Pascal Crépey Pascal Astagneau Lulla Opatowski Laura Temime
author_facet	Narimane Nekkab Pascal Crépey Pascal Astagneau Lulla Opatowski Laura Temime
author_sort	Narimane Nekkab
title	Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015
title_short	Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015
title_full	Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015
title_fullStr	Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015
title_full_unstemmed	Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015
title_sort	assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing enterobacteriaceae: the case of france between 2012 and 2015
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6fb29d6d86da41c48ff6ee40f7792a27
work_keys_str_mv	AT narimanenekkab assessingtheroleofinterfacilitypatienttransferinthespreadofcarbapenemaseproducingenterobacteriaceaethecaseoffrancebetween2012and2015 AT pascalcrepey assessingtheroleofinterfacilitypatienttransferinthespreadofcarbapenemaseproducingenterobacteriaceaethecaseoffrancebetween2012and2015 AT pascalastagneau assessingtheroleofinterfacilitypatienttransferinthespreadofcarbapenemaseproducingenterobacteriaceaethecaseoffrancebetween2012and2015 AT lullaopatowski assessingtheroleofinterfacilitypatienttransferinthespreadofcarbapenemaseproducingenterobacteriaceaethecaseoffrancebetween2012and2015 AT lauratemime assessingtheroleofinterfacilitypatienttransferinthespreadofcarbapenemaseproducingenterobacteriaceaethecaseoffrancebetween2012and2015
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Assessing the role of inter-facility patient transfer in the spread of carbapenemase-producing Enterobacteriaceae: the case of France between 2012 and 2015

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