Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.

Guardado en:

Detalles Bibliográficos
Autores principales:	Li-Wei Tung, Guan-Ling Lu, Yen-Hsien Lee, Lung Yu, Hsin-Jung Lee, Emma Leishman, Heather Bradshaw, Ling-Ling Hwang, Ming-Shiu Hung, Ken Mackie, Andreas Zimmer, Lih-Chu Chiou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6fb8a2e8693f4fcf8b5d51e6da9be8c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6fb8a2e8693f4fcf8b5d51e6da9be8c1
record_format	dspace
spelling	oai:doaj.org-article:6fb8a2e8693f4fcf8b5d51e6da9be8c12021-12-02T17:32:38ZOrexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons10.1038/ncomms121992041-1723https://doaj.org/article/6fb8a2e8693f4fcf8b5d51e6da9be8c12016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12199https://doaj.org/toc/2041-1723Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.Li-Wei TungGuan-Ling LuYen-Hsien LeeLung YuHsin-Jung LeeEmma LeishmanHeather BradshawLing-Ling HwangMing-Shiu HungKen MackieAndreas ZimmerLih-Chu ChiouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li-Wei Tung Guan-Ling Lu Yen-Hsien Lee Lung Yu Hsin-Jung Lee Emma Leishman Heather Bradshaw Ling-Ling Hwang Ming-Shiu Hung Ken Mackie Andreas Zimmer Lih-Chu Chiou Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
description	Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.
format	article
author	Li-Wei Tung Guan-Ling Lu Yen-Hsien Lee Lung Yu Hsin-Jung Lee Emma Leishman Heather Bradshaw Ling-Ling Hwang Ming-Shiu Hung Ken Mackie Andreas Zimmer Lih-Chu Chiou
author_facet	Li-Wei Tung Guan-Ling Lu Yen-Hsien Lee Lung Yu Hsin-Jung Lee Emma Leishman Heather Bradshaw Ling-Ling Hwang Ming-Shiu Hung Ken Mackie Andreas Zimmer Lih-Chu Chiou
author_sort	Li-Wei Tung
title	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_short	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_full	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_fullStr	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_full_unstemmed	Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
title_sort	orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6fb8a2e8693f4fcf8b5d51e6da9be8c1
work_keys_str_mv	AT liweitung orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT guanlinglu orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT yenhsienlee orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT lungyu orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT hsinjunglee orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT emmaleishman orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT heatherbradshaw orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT linglinghwang orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT mingshiuhung orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT kenmackie orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT andreaszimmer orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons AT lihchuchiou orexinscontributetorestraintstressinducedcocainerelapsebyendocannabinoidmediateddisinhibitionofdopaminergicneurons
_version_	1718380254146330624

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Ejemplares similares