Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé

Abstract The lateral habenula (LHb) has an important role in the behavioural response to salient, usually aversive, events. We previously demonstrated that activation of neurons in the LHb increases brown adipose tissue (BAT) thermogenesis and constricts the cutaneous vascular bed, indicating that t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Youichirou Ootsuka, Mazher Mohammed, William W. Blessing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6fb91f1f46014d8389f69be265f8575e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6fb91f1f46014d8389f69be265f8575e
record_format	dspace
spelling	oai:doaj.org-article:6fb91f1f46014d8389f69be265f8575e2021-12-02T11:52:42ZLateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé10.1038/s41598-017-04173-y2045-2322https://doaj.org/article/6fb91f1f46014d8389f69be265f8575e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04173-yhttps://doaj.org/toc/2045-2322Abstract The lateral habenula (LHb) has an important role in the behavioural response to salient, usually aversive, events. We previously demonstrated that activation of neurons in the LHb increases brown adipose tissue (BAT) thermogenesis and constricts the cutaneous vascular bed, indicating that the LHb contributes to the central control of sympathetic outflow to thermoregulatory effector organs. We have now investigated whether the LHb mediates BAT thermogenesis elicited by emotional stress, and whether the LHb modulates thermoregulatory sympathetic outflow via the rostral medullary raphé, a key integrative lower brainstem sympathetic control centre. In conscious animals, lesioning the LHb attenuated emotional BAT thermogenesis, suggesting that the LHb is part of the central circuitry mediating emotional hyperthermia. In anesthetized animals, inhibition of neurons in the rostral medullary raphé reversed BAT thermogenesis and cutaneous vasoconstriction elicited by activation of neurons in the LHb, indicating that the LHb-induced autonomic responses are mediated through activation of the rostral medullary raphé neurons. The latency to activate BAT sympathetic discharge from electrical stimulation of the LHb was substantially greater than the corresponding latency after stimulation of the medullary raphé, suggesting that the neuronal pathway connecting those two nuclei is quite indirect.Youichirou OotsukaMazher MohammedWilliam W. BlessingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Youichirou Ootsuka Mazher Mohammed William W. Blessing Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
description	Abstract The lateral habenula (LHb) has an important role in the behavioural response to salient, usually aversive, events. We previously demonstrated that activation of neurons in the LHb increases brown adipose tissue (BAT) thermogenesis and constricts the cutaneous vascular bed, indicating that the LHb contributes to the central control of sympathetic outflow to thermoregulatory effector organs. We have now investigated whether the LHb mediates BAT thermogenesis elicited by emotional stress, and whether the LHb modulates thermoregulatory sympathetic outflow via the rostral medullary raphé, a key integrative lower brainstem sympathetic control centre. In conscious animals, lesioning the LHb attenuated emotional BAT thermogenesis, suggesting that the LHb is part of the central circuitry mediating emotional hyperthermia. In anesthetized animals, inhibition of neurons in the rostral medullary raphé reversed BAT thermogenesis and cutaneous vasoconstriction elicited by activation of neurons in the LHb, indicating that the LHb-induced autonomic responses are mediated through activation of the rostral medullary raphé neurons. The latency to activate BAT sympathetic discharge from electrical stimulation of the LHb was substantially greater than the corresponding latency after stimulation of the medullary raphé, suggesting that the neuronal pathway connecting those two nuclei is quite indirect.
format	article
author	Youichirou Ootsuka Mazher Mohammed William W. Blessing
author_facet	Youichirou Ootsuka Mazher Mohammed William W. Blessing
author_sort	Youichirou Ootsuka
title	Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
title_short	Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
title_full	Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
title_fullStr	Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
title_full_unstemmed	Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
title_sort	lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6fb91f1f46014d8389f69be265f8575e
work_keys_str_mv	AT youichirouootsuka lateralhabenularegulationofemotionalhyperthermiamediationviathemedullaryraphe AT mazhermohammed lateralhabenularegulationofemotionalhyperthermiamediationviathemedullaryraphe AT williamwblessing lateralhabenularegulationofemotionalhyperthermiamediationviathemedullaryraphe
_version_	1718394930847547392

Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé

Ejemplares similares