Identification of small-molecule ion channel modulators in C. elegans channelopathy models

Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.

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Autores principales:	Qiang Jiang, Kai Li, Wen-Jing Lu, Shuang Li, Xin Chen, Xi-Juan Liu, Jie Yuan, Qiurong Ding, Feng Lan, Shi-Qing Cai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6fbe7f0d2c174c07a41338abdebd0bc4
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spelling	oai:doaj.org-article:6fbe7f0d2c174c07a41338abdebd0bc42021-12-02T15:34:17ZIdentification of small-molecule ion channel modulators in C. elegans channelopathy models10.1038/s41467-018-06514-52041-1723https://doaj.org/article/6fbe7f0d2c174c07a41338abdebd0bc42018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06514-5https://doaj.org/toc/2041-1723Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.Qiang JiangKai LiWen-Jing LuShuang LiXin ChenXi-Juan LiuJie YuanQiurong DingFeng LanShi-Qing CaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiang Jiang Kai Li Wen-Jing Lu Shuang Li Xin Chen Xi-Juan Liu Jie Yuan Qiurong Ding Feng Lan Shi-Qing Cai Identification of small-molecule ion channel modulators in C. elegans channelopathy models
description	Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.
format	article
author	Qiang Jiang Kai Li Wen-Jing Lu Shuang Li Xin Chen Xi-Juan Liu Jie Yuan Qiurong Ding Feng Lan Shi-Qing Cai
author_facet	Qiang Jiang Kai Li Wen-Jing Lu Shuang Li Xin Chen Xi-Juan Liu Jie Yuan Qiurong Ding Feng Lan Shi-Qing Cai
author_sort	Qiang Jiang
title	Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_short	Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_full	Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_fullStr	Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_full_unstemmed	Identification of small-molecule ion channel modulators in C. elegans channelopathy models
title_sort	identification of small-molecule ion channel modulators in c. elegans channelopathy models
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6fbe7f0d2c174c07a41338abdebd0bc4
work_keys_str_mv	AT qiangjiang identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT kaili identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT wenjinglu identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT shuangli identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT xinchen identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT xijuanliu identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT jieyuan identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT qiurongding identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT fenglan identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels AT shiqingcai identificationofsmallmoleculeionchannelmodulatorsinceleganschannelopathymodels
_version_	1718386906273677312

Identification of small-molecule ion channel modulators in C. elegans channelopathy models

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