Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity

Abstract The evidence of the responsiveness of dopaminergic medication on gait in patients with Parkinson’s disease is contradicting. This could be due to differences in complexity of the context gait was in performed. This study analysed the effect of dopaminergic medication on arm swing, an import...

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Autores principales:	Elke Warmerdam, Robbin Romijnders, Clint Hansen, Morad Elshehabi, Milan Zimmermann, Florian G. Metzger, Anna-Katharina von Thaler, Daniela Berg, Gerhard Schmidt, Walter Maetzler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6fc24a6255a14c6fb9e7e33c9d483c05
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spelling	oai:doaj.org-article:6fc24a6255a14c6fb9e7e33c9d483c052021-12-02T18:07:53ZArm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity10.1038/s41531-021-00235-12373-8057https://doaj.org/article/6fc24a6255a14c6fb9e7e33c9d483c052021-10-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00235-1https://doaj.org/toc/2373-8057Abstract The evidence of the responsiveness of dopaminergic medication on gait in patients with Parkinson’s disease is contradicting. This could be due to differences in complexity of the context gait was in performed. This study analysed the effect of dopaminergic medication on arm swing, an important movement during walking, in different contexts. Forty-five patients with Parkinson’s disease were measured when walking at preferred speed, fast speed, and dual-tasking conditions in both OFF and ON medication states. At preferred, and even more at fast speed, arm swing improved with medication. However, during dual-tasking, there were only small or even negative effects of medication on arm swing. Assuming that dual-task walking most closely reflects real-life situations, the results suggest that the effect of dopaminergic medication on mobility-relevant movements, such as arm swing, might be small in everyday conditions. This should motivate further studies to look at medication effects on mobility in Parkinson’s disease, as it could have highly relevant implications for Parkinson’s disease treatment and counselling.Elke WarmerdamRobbin RomijndersClint HansenMorad ElshehabiMilan ZimmermannFlorian G. MetzgerAnna-Katharina von ThalerDaniela BergGerhard SchmidtWalter MaetzlerNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Elke Warmerdam Robbin Romijnders Clint Hansen Morad Elshehabi Milan Zimmermann Florian G. Metzger Anna-Katharina von Thaler Daniela Berg Gerhard Schmidt Walter Maetzler Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity
description	Abstract The evidence of the responsiveness of dopaminergic medication on gait in patients with Parkinson’s disease is contradicting. This could be due to differences in complexity of the context gait was in performed. This study analysed the effect of dopaminergic medication on arm swing, an important movement during walking, in different contexts. Forty-five patients with Parkinson’s disease were measured when walking at preferred speed, fast speed, and dual-tasking conditions in both OFF and ON medication states. At preferred, and even more at fast speed, arm swing improved with medication. However, during dual-tasking, there were only small or even negative effects of medication on arm swing. Assuming that dual-task walking most closely reflects real-life situations, the results suggest that the effect of dopaminergic medication on mobility-relevant movements, such as arm swing, might be small in everyday conditions. This should motivate further studies to look at medication effects on mobility in Parkinson’s disease, as it could have highly relevant implications for Parkinson’s disease treatment and counselling.
format	article
author	Elke Warmerdam Robbin Romijnders Clint Hansen Morad Elshehabi Milan Zimmermann Florian G. Metzger Anna-Katharina von Thaler Daniela Berg Gerhard Schmidt Walter Maetzler
author_facet	Elke Warmerdam Robbin Romijnders Clint Hansen Morad Elshehabi Milan Zimmermann Florian G. Metzger Anna-Katharina von Thaler Daniela Berg Gerhard Schmidt Walter Maetzler
author_sort	Elke Warmerdam
title	Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity
title_short	Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity
title_full	Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity
title_fullStr	Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity
title_full_unstemmed	Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity
title_sort	arm swing responsiveness to dopaminergic medication in parkinson’s disease depends on task complexity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6fc24a6255a14c6fb9e7e33c9d483c05
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Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity

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